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ID3 contributes to cerebrospinal fluid seeding and poor prognosis in medulloblastoma

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dc.contributor.authorPhi, Ji Hoon-
dc.contributor.authorChoi, Seung Ah-
dc.contributor.authorLim, Sang-Hee-
dc.contributor.authorLee, Joongyub-
dc.contributor.authorWang, Kyu-Chang-
dc.contributor.authorPark, Sung-Hye-
dc.contributor.authorKim, Seung-Ki-
dc.date.accessioned2013-06-19T08:31:22Z-
dc.date.available2013-06-19T08:31:22Z-
dc.date.issued2013-06-15-
dc.identifier.citationBMC Cancer. Vol.13ko_KR
dc.identifier.issn1471-2407-
dc.identifier.urihttp://www.biomedcentral.com/1471-2407/13/291-
dc.identifier.urihttps://hdl.handle.net/10371/82820-
dc.description.abstractBackground : The inhibitor of differentiation (ID) genes have been implicated as promoters of tumor progression and metastasis in many human cancers. The current study investigated the expression and functional roles of ID genes in seeding and prognosis of medulloblastoma.

Methods : ID gene expression was screened in human medulloblastoma tissues. Knockdown of ID3 gene was performed in medulloblastoma cells in vitro. The expression of metastasis-related genes after ID3 knockdown was assessed. The effect of ID3 knockdown on tumor seeding was observed in an animal model in vivo. The survival of medulloblastoma patients was plotted according to the ID3 expression levels.

Results : Significantly higher ID3 expression was observed in medulloblastoma with cerebrospinal fluid seeding than tumors without seeding. Knockdown of ID3 decreased proliferation, increased apoptosis, and suppressed the migration of D283 medulloblastoma cells in vitro. In a seeding model of medulloblastoma, ID3 knockdown in vivo with shRNA inhibited the growth of primary tumors, prevented the development of leptomeningeal seeding, and prolonged animal survival. High ID3 expression was associated with shorter survival of medulloblastoma patients, especially in Group 4 medulloblastomas.

Conclusions : High ID3 expression is associated with medullolbastoma seeding and is a poor prognostic factor, especially in patients with Group 4 tumors. ID3 may represent the metastatic/ aggressive phenotype of a subgroup of medulloblastoma.
ko_KR
dc.description.sponsorshipThis work was supported by the National Research Foundation of Korea(NRF) grant funded by the Korea government (MEST) (2012011770) and a grant (no.03-2011-008) from the Seoul National University Hospital Research Fund.ko_KR
dc.language.isoenko_KR
dc.publisherBioMed Central Ltdko_KR
dc.subjectID3ko_KR
dc.subjectMedulloblastomako_KR
dc.subjectSeedingko_KR
dc.subjectPrognosisko_KR
dc.subjectSurvivalko_KR
dc.subjectGroup 4ko_KR
dc.titleID3 contributes to cerebrospinal fluid seeding and poor prognosis in medulloblastomako_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor피지훈-
dc.contributor.AlternativeAuthor최승아-
dc.contributor.AlternativeAuthor임상희-
dc.contributor.AlternativeAuthor이중엽-
dc.contributor.AlternativeAuthor왕규창-
dc.contributor.AlternativeAuthor박성혜-
dc.contributor.AlternativeAuthor김승기-
dc.identifier.doi10.1186/1471-2407-13-291-
dc.language.rfc3066en-
dc.description.versionPeer Reviewed-
dc.rights.holderJi Phi et al.; licensee BioMed Central Ltd.-
dc.date.updated2013-06-19T06:01:16Z-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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