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Poly(ester amine)-mediated, aerosol-delivered Akt1 small interfering RNA suppresses lung tumorigenesis
DC Field | Value | Language |
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dc.contributor.author | Xu, Cheng-Xiong | - |
dc.contributor.author | Jere, Dhananjay | - |
dc.contributor.author | Jin, Hua | - |
dc.contributor.author | Chang, Seung-Hee | - |
dc.contributor.author | Chung, Youn-Sun | - |
dc.contributor.author | Shin, Ji-Young | - |
dc.contributor.author | Kim, Ji-Eun | - |
dc.contributor.author | Park, Sung-Jin | - |
dc.contributor.author | Lee, Yong-Hoon | - |
dc.contributor.author | Chae, Chan-Hee | - |
dc.contributor.author | Lee, Kee Ho | - |
dc.contributor.author | Beck, George R., Jr. | - |
dc.contributor.author | Cho, Chong-Su | - |
dc.contributor.author | Cho, Myung-Haing | - |
dc.date.accessioned | 2009-08-31T23:28:35Z | - |
dc.date.available | 2009-08-31T23:28:35Z | - |
dc.date.created | 2018-01-22 | - |
dc.date.issued | 2008-07 | - |
dc.identifier.citation | American Journal of Respiratory and Critical Care Medicine, Vol.178 No.1, pp.60-73 | - |
dc.identifier.issn | 1073-449X | - |
dc.identifier.other | 25410 | - |
dc.identifier.uri | https://hdl.handle.net/10371/8283 | - |
dc.description.abstract | Rationale: The low efficiency of conventional therapies in achieving long-term survival of patients with lung cancer calls for the development of novel therapeutic options. Recent advances in aerosol-mediated gene delivery have provided the possibility of an alternative for the safe and effective treatment of lung cancer. Objectives: To demonstrate the feasibility and emphasize the importance of noninvasive aerosol delivery of Akt1 small interfering RNA (siRNA) as an effective and selective option for lung cancer treatment. Methods: Nanosized poly(ester amine) polymer was synthesized and used as a gene carrier. An aerosol of poly(ester amine)/Akt1 siRNA complex was delivered into K-ras(LA1) and urethane-induced lung cancer models through a nose-only inhalation system. The effects of Akt1 siRNA on lung cancer progression and Akt-related signals were evaluated. Measurements and Main Results: The aerosol-delivered Akt1 siRNA suppressed lung tumor progression significantly through inhibiting Akt-related signals and cell cycle, Conclusions: The use of poly(ester amine) serves as an effective carrier, and aerosol delivery of Akt1 siRNA may be a promising approach for lung cancer treatment and prevention. | - |
dc.language | 영어 | - |
dc.language.iso | en | en |
dc.publisher | American Thoracic Society | - |
dc.title | Poly(ester amine)-mediated, aerosol-delivered Akt1 small interfering RNA suppresses lung tumorigenesis | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 조명행 | - |
dc.identifier.doi | 10.1164/rccm.200707-1022OC | - |
dc.citation.journaltitle | American Journal of Respiratory and Critical Care Medicine | - |
dc.identifier.wosid | 000257199800012 | - |
dc.identifier.scopusid | 2-s2.0-46349111796 | - |
dc.citation.endpage | 73 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 60 | - |
dc.citation.volume | 178 | - |
dc.identifier.sci | 000257199800012 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Chae, Chan-Hee | - |
dc.contributor.affiliatedAuthor | Cho, Myung-Haing | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | AKT/PROTEIN KINASE-B | - |
dc.subject.keywordPlus | HUMAN TUMOR-CELLS | - |
dc.subject.keywordPlus | K-RAS | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | PROTEIN-KINASE | - |
dc.subject.keywordPlus | GENE DELIVERY | - |
dc.subject.keywordPlus | MAMMALIAN TARGET | - |
dc.subject.keywordPlus | CANCER CELLS | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordAuthor | poly(ester amine) | - |
dc.subject.keywordAuthor | Akt1 siRNA | - |
dc.subject.keywordAuthor | lung cancer | - |
dc.subject.keywordAuthor | K-ras(LA1) mice | - |
dc.subject.keywordAuthor | urethane | - |
dc.subject.keywordAuthor | aerosol gene delivery | - |
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