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Time- and Dose-based Gene Expression Profiles Produced by a Bile-duct-damaging Chemical, 4,4'-methylene Dianiline, in Mouse Liver in an Acute Phase
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kwon, Sun-Bom | - |
dc.contributor.author | Park, Joon-Suk | - |
dc.contributor.author | Yi, Jung-Yeon | - |
dc.contributor.author | Hwang, Jae-Wong | - |
dc.contributor.author | Kim, Mingoo | - |
dc.contributor.author | Lee, Mi-Ock | - |
dc.contributor.author | Lee, Byung-Hoon | - |
dc.contributor.author | Kim, Hyung-Lae | - |
dc.contributor.author | Kim, Ju Han | - |
dc.contributor.author | Chung, Heekyoung | - |
dc.contributor.author | Kong, Gu | - |
dc.contributor.author | Kang, Kyung-Sun | - |
dc.contributor.author | Yoon, Byung-Il | - |
dc.date.accessioned | 2009-08-31T23:32:11Z | - |
dc.date.available | 2009-08-31T23:32:11Z | - |
dc.date.issued | 2008-07-22 | - |
dc.identifier.citation | Toxicol Pathol 36, 660-73 | en |
dc.identifier.issn | 0192-6233 (print) | - |
dc.identifier.issn | 1533-1601 (online) | - |
dc.identifier.uri | https://hdl.handle.net/10371/8285 | - |
dc.description.abstract | A toxicogenomics study was performed in the mouse liver after treatment of a bile-duct–damaging chemical, 4,4-methylene dianiline (MDA), across
multiple doses and sampling times in an acute phase using the AB Expression Array System. Imprinting control region (ICR) mice were given a single oral administration of a low (10 mg/kg b.w.) or high (100 mg/kg b.w.) dose of MDA. Mice were sacrificed six, twenty-four, and seventy-two hours after treatment for serum chemistry, histopathology, and mRNA preparation from liver samples. Treatment with MDA increased liver-toxicity–related enzymes in blood and induced bile-duct cell injury, followed by regeneration. To explore potential biomarker gene profiles, the altered genes were categorized into four expression patterns depending on dose and time. Numerous functionally defined and unclassified genes in each category were up- or down-regulated throughout the period from cellular injury to the recovery phase, verified by RT-PCR. Many genes associated with liver toxicity and diseases belonged to one of these categories. The chemokine-mediated Th1 pathway was implicated in the inflammatory process. The genes associated with oxidative stress, apoptosis, and cell-cycle regulation were also dynamically responsive to MDA treatment. The Wnt/β-catenin signaling pathway was likely responsible for the reconstitution process of the MDA-injured liver. | en |
dc.description.sponsorship | This work was supported by a grant from the Korea Food
and Drug Administration (KFDA-05122-TGP-584). | en |
dc.language.iso | en | en |
dc.publisher | Taylor & Francis | en |
dc.subject | acute liver toxicity | en |
dc.subject | 4,4’-methylene dianiline | en |
dc.subject | mouse | en |
dc.subject | toxicogenomics | en |
dc.title | Time- and Dose-based Gene Expression Profiles Produced by a Bile-duct-damaging Chemical, 4,4'-methylene Dianiline, in Mouse Liver in an Acute Phase | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 권선봄 | - |
dc.contributor.AlternativeAuthor | 박준석 | - |
dc.contributor.AlternativeAuthor | 이정연 | - |
dc.contributor.AlternativeAuthor | 황재웅 | - |
dc.contributor.AlternativeAuthor | 김민구 | - |
dc.contributor.AlternativeAuthor | 이미옥 | - |
dc.contributor.AlternativeAuthor | 이병훈 | - |
dc.contributor.AlternativeAuthor | 김형래 | - |
dc.contributor.AlternativeAuthor | 김주한 | - |
dc.contributor.AlternativeAuthor | 정희경 | - |
dc.contributor.AlternativeAuthor | 공구 | - |
dc.contributor.AlternativeAuthor | 강경선 | - |
dc.contributor.AlternativeAuthor | 윤병일 | - |
dc.identifier.doi | 10.1177/0192623308320272 | - |
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