S-Space College of Veterinary Medicine (수의과대학) Dept. of Veterinary Medicine (수의학과) Journal Papers (저널논문_수의학과)
The anti-inflammatory drug Diclofenac retains anti-listerial activity in vivo
- Dutta, N.K.; Mazumdar, K.; Seok, S.H.; Park, Jae Hak
- Issue Date
- Lett Appl Microbiol 47, 106-111
- Aims: The interactions between nonsteroidal anti-inflammatory drugs (NSAID) and Listeria monocytogenes have not been sufficiently documented to date. The aim of this study was to investigate the possible effects of Diclofenac (Dc) in a murine listerial infection model. Methods and Results: Dc was administered orally at 2·5 μg g−1 to female albino strain of laboratory mouse (BALB/c) thrice postinfection (1 × 108 CFU ml−1 oral challenge with L. monocytogenes ATCC 51774), which resulted in significantly ( P < 0·01) reduced bacterial counts in liver and spleen, decreased (10-fold, P < 0·05) hepatic colonization and necrosis, and caused up-regulation of the expression of inflammatory cytokines (interferon-γ, interleukin-1β, tumour necrosis factor-α), compared with drug-free control. Conclusions: Dc may be useful as a promising adjuvant to the existing therapies in controlling systemic listerial infection. Further, quantitative structure–activity relationship studies might contribute in manipulating it as a lead compound for the synthesis of new, more effective nonantibiotics, perhaps, devoid of side-effects that could be recommended as a compassionate therapy for listeriosis. Significance and Impact of the study: This is the first in vivo study designed to evaluate the antilisterial effect of the NSAID Dc with special emphasis on the immunological mechanism of action of the drug.
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