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The anti-inflammatory drug Diclofenac retains anti-listerial activity in vivo

Cited 14 time in Web of Science Cited 18 time in Scopus
Authors
Dutta, N.K.; Mazumdar, K.; Seok, S.H.; Park, Jae Hak
Issue Date
2008
Publisher
Wiley-Blackwell
Citation
Lett Appl Microbiol 47, 106-111
Keywords
Diclofenacin vivo activityListeria monocytogenes
Abstract
Aims: The interactions between nonsteroidal anti-inflammatory drugs (NSAID) and Listeria monocytogenes have not been sufficiently documented to date. The aim of this study was to investigate the possible effects of Diclofenac (Dc) in a murine listerial infection model. Methods and Results: Dc was administered orally at 2·5 μg g−1 to female albino strain of laboratory mouse (BALB/c) thrice postinfection (1 × 108 CFU ml−1 oral challenge with L. monocytogenes ATCC 51774), which resulted in significantly ( P < 0·01) reduced bacterial counts in liver and spleen, decreased (10-fold, P < 0·05) hepatic colonization and necrosis, and caused up-regulation of the expression of inflammatory cytokines (interferon-γ, interleukin-1β, tumour necrosis factor-α), compared with drug-free control. Conclusions: Dc may be useful as a promising adjuvant to the existing therapies in controlling systemic listerial infection. Further, quantitative structure–activity relationship studies might contribute in manipulating it as a lead compound for the synthesis of new, more effective nonantibiotics, perhaps, devoid of side-effects that could be recommended as a compassionate therapy for listeriosis. Significance and Impact of the study: This is the first in vivo study designed to evaluate the antilisterial effect of the NSAID Dc with special emphasis on the immunological mechanism of action of the drug.
ISSN
0266-8254
Language
English
URI
http://hdl.handle.net/10371/8294
DOI
https://doi.org/10.1111/j.1472-765X.2008.02391.x
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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