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The effect of the DLTIDDSYWYRI motif of the human laminin α2 chain on implant osseointegration

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dc.contributor.authorKang, Hyun Ki-
dc.contributor.authorKim, O Bok-
dc.contributor.authorMin, Seung-Ki-
dc.contributor.authorJung, Sung Youn-
dc.contributor.authorJang, Da Hyun-
dc.contributor.authorKwon, Taek-Ka-
dc.contributor.authorMin, Byung-Moo-
dc.contributor.authorYeo, In-Sung-
dc.creator여인성-
dc.date.accessioned2013-07-19T02:16:44Z-
dc.date.available2013-07-19T02:16:44Z-
dc.date.issued2013-05-
dc.identifier.citationBiomaterials Vol.34 No.16, pp. 4027-4037-
dc.identifier.issn0142-9612-
dc.identifier.urihttps://hdl.handle.net/10371/83019-
dc.description.abstractConsiderable effort has been directed towards replacing lost teeth using tissue-engineering methods such as titanium implants. A number of studies have tried to modify bioinert titanium surfaces by coating them with functionally bioactive molecules for faster and stronger osseointegration than pure titanium surfaces. Recently, peptides have been recognized as valuable scientific tools in the field of tissue-engineering. The DLTIDDSYWYRI motif of the human laminin-2 α2 chain has been previously reported to promote the attachment of various cell types; however, the in vivo effects of the DLTIDDSYWYRI motif on new bone formation have not yet been studied. To examine whether a laminin-2-derived peptide can promote osseointegration by accelerating new bone formation in vivo, we applied titanium implants coated with the DLTIDDSYWYRI motif in a rabbit tibia model. The application of the DLTIDDSYWYRI motif-treated implant to tibia wounds enhanced collagen deposition and alkaline phosphatase expression. It significantly promoted implant osseointegration compared with treatment with scrambled peptide-treated implants by increasing the bone-to-implant contact ratio and bone area. These findings support the hypothesis that the DLTIDDSYWYRI motif acts as an effective osseointegration accelerator by enhancing new bone formation.en
dc.description.abstractConsiderable effort has been directed towards replacing lost teeth using tissue-engineering methods such as titanium implants. A number of studies have tried to modify bioinert titanium surfaces by coating them with functionally bioactive molecules for faster and stronger osseointegration than pure titanium surfaces. Recently, peptides have been recognized as valuable scientific tools in the field of tissue-engineering. The DLTIDDSYWYRI motif of the human laminin-2 α2 chain has been previously reported to promote the attachment of various cell types; however, the in vivo effects of the DLTIDDSYWYRI motif on new bone formation have not yet been studied. To examine whether a laminin-2-derived peptide can promote osseointegration by accelerating new bone formation in vivo, we applied titanium implants coated with the DLTIDDSYWYRI motif in a rabbit tibia model. The application of the DLTIDDSYWYRI motif-treated implant to tibia wounds enhanced collagen deposition and alkaline phosphatase expression. It significantly promoted implant osseointegration compared with treatment with scrambled peptide-treated implants by increasing the bone-to-implant contact ratio and bone area. These findings support the hypothesis that the DLTIDDSYWYRI motif acts as an effective osseointegration accelerator by enhancing new bone formation.-
dc.description.abstractTissue-engineering-
dc.description.sponsorshipThis work was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by MEST (Grant No. 2011-0007662) and the Mid-career Researcher Program through NRF, funded by MEST (Grant No. 2010-0014662).-
dc.language.isoenen
dc.publisherElsevier Ltden
dc.subject의약학en
dc.subjectLaminin-2-derived peptide-
dc.subjectTitanium implant-
dc.subjectOsseointegration-
dc.subjectBone-to-implant contact ratio-
dc.titleThe effect of the DLTIDDSYWYRI motif of the human laminin α2 chain on implant osseointegrationen
dc.typeArticle-
dc.author.alternative강현기-
dc.author.alternative김오복-
dc.author.alternative민승기-
dc.author.alternative정성윤-
dc.author.alternative장다현-
dc.author.alternative권택가-
dc.author.alternative민병무-
dc.author.alternative여인성-
dc.identifier.doi10.1016/j.biomaterials.2013.02.023-
dc.citation.journaltitleBiomaterials-
dc.description.srndOAIID:oai:osos.snu.ac.kr:snu2013-01/102/2008003883/1-
dc.description.srndSEQ:1-
dc.description.srndPERF_CD:SNU2013-01-
dc.description.srndEVAL_ITEM_CD:102-
dc.description.srndUSER_ID:2008003883-
dc.description.srndADJUST_YN:N-
dc.description.srndEMP_ID:A078517-
dc.description.srndDEPT_CD:861-
dc.description.srndCITE_RATE:7.404-
dc.description.srndFILENAME:Biomaterials 201305 34(16) 4027-37.pdf-
dc.description.srndDEPT_NM:치의학과-
dc.description.srndEMAIL:pros53@snu.ac.kr-
dc.description.srndSCOPUS_YN:Y-
dc.description.srndCONFIRM:Y-
dc.identifier.srnd2013-01/102/2008003883/1-
Appears in Collections:
College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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