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Otologic Manifestation in IgG4-Related Systemic Disease
Cited 31 time in
Web of Science
Cited 32 time in Scopus
- Authors
- Issue Date
- 2011-05
- Citation
- Clinical and Experimental Otorhinolaryngology Vol.4 No.1, pp. 52-54
- Keywords
- 의약학 ; Immunoglobulin G ; Hearing loss ; Autoimmune disease
- Abstract
- IgG4-related systemic disease, including autoimmune pancreatitis, is a multi-organ disorder characterized by elevated serum immunoglobulin G4 (IgG4) concentration and IgG4-positive plasma cell infiltration. We report a case of a 66-years-old woman with IgG4-related hearing disorder, presenting with fluctuating mixed hearing loss with middle ear effusion. The serum IgG4 level was elevated and pathological examination revealed dense infiltration of IgG4-positive lymphocyte in the renal parenchyma, lung tissue and lacrimal gland. With intravenous methylprednisolone at a dose of 60 mg daily, improvement of hearing loss were observed. No recurrence was observed for 6 months with mainternance of prednisolone and methotrexate.
- ISSN
- 1976-8710
2005-0720(eISSN)
- Language
- English
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