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Effects of Pregnane X Receptor (NR1I2) and CYP2B6 Genetic Polymorphisms on the Induction of Bupropion Hydroxylation by Rifampin
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chung, Jae Yong | - |
dc.contributor.author | Cho, Joo-Youn | - |
dc.contributor.author | Lim, Hyeong-Seok | - |
dc.contributor.author | Kim, Jung-Ryul | - |
dc.contributor.author | Yu, Kung-Sang | - |
dc.contributor.author | Lim, Kyoung Soo | - |
dc.contributor.author | Shin, Sang-Goo | - |
dc.contributor.author | Jang, In-Jin | - |
dc.creator | 정재용 | - |
dc.date.accessioned | 2013-08-07T04:14:28Z | - |
dc.date.available | 2013-08-07T04:14:28Z | - |
dc.date.issued | 2011-01 | - |
dc.identifier.citation | Drug Metabolism and Disposition Vol.39 No.1, pp. 92-97 | - |
dc.identifier.issn | 0090-9556 | - |
dc.identifier.uri | https://hdl.handle.net/10371/83259 | - |
dc.description.abstract | We investigated genetic polymorphisms in the pregnane X receptor (NR1I2) in Korean individuals (n = 83) and the effects of NR1I2 genotypes on rifampin-mediated induction of bupropion hydroxylation. The pharmacokinetics of bupropion and hydroxybupropion were evaluated after an oral dose of bupropion (150 mg) administered before and after rifampin treatment for 7 days in 35 healthy subjects. The area under the time-concentration curve (AUC) ratio of hydroxybupropion to bupropion in CYP2B6*6 carriers was significantly lower than that in CYP2B6*6 noncarriers in both the basal and rifampin-induced states (p = 0.012). Among the CYP2B6*6 carriers (n = 13), the NR1I2 TGT (-25385T + g.7635G + g.8055T) carriers exhibited a significantly lower AUC ratio, representing the CYP2B6 hydroxylation activity, compared with the TGT noncarriers, in the induced state (11.9 versus 20.3, p = 0.045). The percent difference in the AUC ratio between the basal and induced states was also significantly different (212% versus 58.8%, p = 0.006). However, no significant difference was observed among the NR1I2 TGT genotypes for the CYP2B6*6 noncarriers (n = 22). In conclusion, it is suggested the NR1I2 TGT genotype decreases the bupropion hydroxylation induced by treatment with rifampin, particularly in CYP2B6*6 carriers. | en |
dc.description.sponsorship | This study was supported by the Korea Healthcare Technology R&D Project, Ministry for Health and Welfare, Republic of Korea [Grant A030001]. | - |
dc.language.iso | en | en |
dc.publisher | The American Society for Pharmacology and Experimental herapeutics | en |
dc.subject | 복합학 | en |
dc.title | Effects of Pregnane X Receptor (NR1I2) and CYP2B6 Genetic Polymorphisms on the Induction of Bupropion Hydroxylation by Rifampin | en |
dc.type | Article | - |
dc.author.alternative | 정재용 | - |
dc.author.alternative | 조주연 | - |
dc.author.alternative | 임형석 | - |
dc.author.alternative | 김정렬 | - |
dc.author.alternative | 유경상 | - |
dc.author.alternative | 임경수 | - |
dc.author.alternative | 신상구 | - |
dc.author.alternative | 장인진 | - |
dc.identifier.doi | 10.1124/dmd.110.035246 | - |
dc.citation.journaltitle | Drug Metabolism and Disposition | - |
dc.description.srnd | OAIID:oai:osos.snu.ac.kr:snu2011-01/102/0000050045/4 | - |
dc.description.srnd | SEQ:4 | - |
dc.description.srnd | PERF_CD:SNU2011-01 | - |
dc.description.srnd | EVAL_ITEM_CD:102 | - |
dc.description.srnd | USER_ID:0000050045 | - |
dc.description.srnd | ADJUST_YN:Y | - |
dc.description.srnd | EMP_ID:A078941 | - |
dc.description.srnd | DEPT_CD:801 | - |
dc.description.srnd | CITE_RATE:3.733 | - |
dc.description.srnd | FILENAME:첨부된 내역이 없습니다. | - |
dc.description.srnd | DEPT_NM:의학과 | - |
dc.description.srnd | EMAIL:mekka@snu.ac.kr | - |
dc.description.srnd | SCOPUS_YN:Y | - |
dc.description.srnd | CONFIRM:Y | - |
dc.identifier.srnd | 2011-01/102/0000050045/4 | - |
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