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Enhanced efficacy of 7-hydroxy-3-methoxycadalene via glycosylation in in vivo xenograft study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Hyang Yeon | - |
dc.contributor.author | Kwon, Jung-Taek | - |
dc.contributor.author | Koh, Minseob | - |
dc.contributor.author | Cho, Myung-Haing | - |
dc.contributor.author | Park, Seung Bum | - |
dc.date.accessioned | 2009-09-01 | - |
dc.date.available | 2009-09-01 | - |
dc.date.issued | 2007-09-01 | - |
dc.identifier.citation | Bioorg. Med. Chem. Lett. 2007, 17, 6335-6339 | en |
dc.identifier.issn | 0960-894X | - |
dc.identifier.uri | https://hdl.handle.net/10371/8342 | - |
dc.description.abstract | 7-Hydroxy-3-methoxycadalene, isolated from Zelkova serrata Makino, was confirmed as a biologically active natural compound. In this study, the efficacy of cadalene as an anticancer agent was tested. In order to address the poor physicochemical properties of cadalene, we designed and synthesized glycosylated cadalene derivatives for improved solubility and efficient drug delivery as a potential prodrug. In vitro cell viability assays confirmed that glycosylated cadalenes were less toxic and more soluble than cadalene. In an in vivo xenograft study in mice, the oral administration of glycosylated cadalenes caused a significant reduction in tumor size. | en |
dc.description.sponsorship | This work is supported by the Korea Science and Engineering Foundation (KOSEF); Molecular and Cellular BioDiscovery Research Program of the Ministry of Science and Technology (MOST); and MarineBio21, Ministry of Maritime Affairs and Fisheries, Korea (MOMAF). M.H.C. is supported by KOSEF (M20704000010-07M0400-01010). H.Y. Lee is grateful for the Seoul Science Fellowship award. H.Y. Lee, J.T. Kwon, and M. Koh are grateful for the BK21 fellowship award. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Cadalene | en |
dc.subject | Glycosylation | en |
dc.subject | Prodrug | en |
dc.subject | Drug delivery | en |
dc.subject | Anticancer | en |
dc.title | Enhanced efficacy of 7-hydroxy-3-methoxycadalene via glycosylation in in vivo xenograft study | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 이향련 | - |
dc.contributor.AlternativeAuthor | 권정택 | - |
dc.contributor.AlternativeAuthor | 고민섭 | - |
dc.contributor.AlternativeAuthor | 조명행 | - |
dc.contributor.AlternativeAuthor | 박승범 | - |
dc.identifier.doi | 10.1016/j.bmcl.2007.08.071 | - |
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