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Pretreatment of epidermal growth factor promotes primary hair recovery via the dystrophic anagen pathway after chemotherapy-induced alopecia

Cited 14 time in Web of Science Cited 16 time in Scopus
Authors
Paik, Seung Hwan; Yoon, Ji-Seon; Ryu, Hyeong Ho; Lee, Ji Yeon; Shin, Chang Yup; Min, Kyung Hyun; Jo, Seong Jin; Kim, Kyu Han; Kwon, Ohsang
Issue Date
2013-07
Publisher
John Wiley & Sons
Citation
Experimental Dermatology Vol.22 No.7, pp. 496-499
Keywords
의약학chemotherapy-induced alopeciadystrophic anagen pathwayepidermal growth factorprimary hair recovery
Abstract
Epidermal growth factor (EGF) is not only a cell growth stimulant but also has a catagen-inducing effect. Because chemotherapeutic agents primarily damage anagen hair follicles, it would be important to investigate whether catagen inducers have beneficial effects in chemotherapy-induced alopecia (CIA). We pretreated hair follicles with topical EGF-liposomal solution in the C57BL/6 mouse model of cyclophosphamide-induced alopecia and observed the catagen-inducing property and damage response pathway after CIA. We confirmed that topical EGF application induced a catagen-like stage and found that these catagen-like hairs were protected from chemotherapy-mediated damage. Moreover, our results showed that EGF treatment favoured primary hair recovery via the dystrophic anagen pathway after CIA. Given that hair follicles subjected to less severe chemotherapeutic insult enter the dystrophic anagen pathway followed by primary recovery, the results of this study suggest that catagen inducers could be useful as a new alopecia-protection strategy, especially in the context of CIA.
ISSN
0906-6705 (print)
1600-0625 (online)
Language
English
URI
http://hdl.handle.net/10371/83437
DOI
https://doi.org/10.1111/exd.12182
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)Journal Papers (저널논문_의학과)
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