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Effect of beraprost sodium on arterial stiffness in patients with type 2 diabetic nephropathy

Cited 5 time in Web of Science Cited 3 time in Scopus
Authors
Na, Ki Young; Kim, Dong Ki; Kim, Sung Gyun; Lee, Young-Ki; Lim, Chun Soo
Issue Date
2013-09-02
Publisher
BioMed Central Ltd.
Citation
Trials Vol.14 No.275, pp. 1-6
Keywords
Beraprost sodiumArterial stiffnessDiabetic nephropathyCardiovascularPulse wave velocity
Description
Trial registration : ClinicalTrials.gov number NCT01796418
Abstract
Background : Diabetic nephropathy is the leading cause of end-stage renal disease (ESRD). Cardiovascular (CV) complications are the most common cause of death among ESRD patients. Beraprost sodium (BPS) is a prostacyclin analog with vasodilatory and antiplatelet effects.
Methods : This is a multicenter prospective, randomized, double-blind, placebo-controlled trial to determine whether treatment with BPS improves arterial stiffness in patients with type 2 diabetic nephropathy. A total of 102 participants with type 2 diabetic nephropathy will be screened, enrolled, and randomly assigned to receive either 80 μg BPS or placebo daily for 12 weeks. The primary outcome is the change in brachial-ankle pulse wave velocity between baseline and after 12 weeks of medication use. The secondary outcomes will include changes in the ankle-brachial index, the urine albumin to creatinine ratio, the estimated glomerular filtration rate, lipid profiles, and blood pressure from baseline to after treatment.
Discussion : This clinical trial is the first to investigate the effects of BPS on changes in CV biomarkers, albuminuria, renal function, and lipid profiles in patients with diabetic nephropathy.
ISSN
1745-6215
Language
English
URI
http://hdl.handle.net/10371/83495

http://www.trialsjournal.com/content/14/1/275
DOI
https://doi.org/10.1186/1745-6215-14-275
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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