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Induction of transforming growth factor-beta 1 by androgen is mediated by reactive oxygen species in hair follicle dermal papilla cells
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Shin, Hyoseung | - |
| dc.contributor.author | Yoo, Hyeon Gyeong | - |
| dc.contributor.author | Inui, Shigeki | - |
| dc.contributor.author | Itami, Satoshi | - |
| dc.contributor.author | Kim, In Gyu | - |
| dc.contributor.author | Cho, A-Ri | - |
| dc.contributor.author | Lee, Dong Hun | - |
| dc.contributor.author | Park, Won Seok | - |
| dc.contributor.author | Kwon, Ohsang | - |
| dc.contributor.author | Cho, Kwang Hyun | - |
| dc.contributor.author | Won, Chong Hyun | - |
| dc.creator | 권오상 | - |
| dc.date.accessioned | 2013-10-23T04:33:07Z | - |
| dc.date.available | 2013-10-23T04:33:07Z | - |
| dc.date.issued | 2013-09-30 | - |
| dc.identifier.citation | BMB Reports Vol.46 No.9, pp. 460-464 | - |
| dc.identifier.issn | 1976-670X (online) | - |
| dc.identifier.uri | https://hdl.handle.net/10371/83754 | - |
| dc.description.abstract | The progression of androgenetic alopecia is closely related toandrogen-inducible transforming growth factor (TGF)-β1 secretionby hair follicle dermal papilla cells (DPCs) in bald scalp.Physiological levels of androgen exposure were reported toincrease reactive oxygen species (ROS) generation. In thisstudy, rat vibrissae dermal papilla cells (DP-6) transfected withandrogen receptor showed increased ROS production followingandrogen treatment. We confirmed that TGF-β1 secretion isincreased by androgen treatment in DP-6, whereas androgeninducibleTGF-β1 was significantly suppressed by the ROSscavenger,N-acetyl cysteine. Therefore, we suggest that inductionof TGF-β1 by androgen is mediated by ROS in hair follicleDPCs. | en |
| dc.description.sponsorship | This study was supported by a grant from the Korea Healthcare Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (Grant No. A103017) and partially by a research agreement with AmorePacific Corporation, Republic of Korea. | - |
| dc.language.iso | en | en |
| dc.publisher | The Korean Society for Biochemistry and Molecular Biology | en |
| dc.subject | 자연과학 | en |
| dc.subject | Androgenetic alopecia | - |
| dc.subject | Androgen receptor | - |
| dc.subject | Dermal papilla | - |
| dc.subject | Reactive oxygen species | - |
| dc.subject | Transforming growth factors | - |
| dc.title | Induction of transforming growth factor-beta 1 by androgen is mediated by reactive oxygen species in hair follicle dermal papilla cells | en |
| dc.type | Article | - |
| dc.author.alternative | 신효승 | - |
| dc.author.alternative | 유현경 | - |
| dc.author.alternative | 김인규 | - |
| dc.author.alternative | 조아리 | - |
| dc.author.alternative | 이동훈 | - |
| dc.author.alternative | 박원석 | - |
| dc.author.alternative | 권오상 | - |
| dc.author.alternative | 조광현 | - |
| dc.author.alternative | 원종현 | - |
| dc.identifier.doi | 10.5483/BMBRep.2013.46.9.228 | - |
| dc.citation.journaltitle | BMB Reports | - |
| dc.description.srnd | OAIID:oai:osos.snu.ac.kr:snu2013-01/102/0000045457/8 | - |
| dc.description.srnd | SEQ:8 | - |
| dc.description.srnd | PERF_CD:SNU2013-01 | - |
| dc.description.srnd | EVAL_ITEM_CD:102 | - |
| dc.description.srnd | USER_ID:0000045457 | - |
| dc.description.srnd | ADJUST_YN:N | - |
| dc.description.srnd | EMP_ID:A079130 | - |
| dc.description.srnd | DEPT_CD:801 | - |
| dc.description.srnd | CITE_RATE:1.634 | - |
| dc.description.srnd | FILENAME:(460-464)bmb 12-228.pdf | - |
| dc.description.srnd | DEPT_NM:의학과 | - |
| dc.description.srnd | EMAIL:oskwon@snu.ac.kr | - |
| dc.description.srnd | SCOPUS_YN:Y | - |
| dc.description.srnd | CONFIRM:Y | - |
| dc.identifier.srnd | 2013-01/102/0000045457/8 | - |
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