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Signal crosstalk between estrogen and peroxisome proliferator-activated receptor α on adiposity
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- Authors
- Issue Date
- 2008
- Citation
- BMB Rep. 42, 91-95
- Keywords
- Estrogen ; LPL ; Obesity ; PPARα ; Signaling crosstalk
- Abstract
- Peroxisome proliferator-activated receptor α and estrogen are
believed to be involved in metabolic changes leading to obesity.
To test this relationship, we divided female wildtype and
PPARα-deficient mice fed on a high fat diet into the following
groups: mock-operated, ovariectomized (OVX), and E2-treated.
The visceral white adipose tissue and plasma cholesterol levels
were increased significantly in wild type OVX and decreased in
the E2-treated group, but interestingly not in PPARα-deficient
mice. The mRNA levels of lipoprotein lipase in adipose tissue
were also increased in only wild type OVX and decreased significantly
in E2-treated mice. These novel results suggest the possibility
of signaling crosstalk between PPARα and E2, causing
obesity in vivo.
- ISSN
- 1976-6696
- Language
- English
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