S-Space College of Engineering/Engineering Practice School (공과대학/대학원) Dept. of Electrical and Computer Engineering (전기·정보공학부) Journal Papers (저널논문_전기·정보공학부)
Cellular Responses to Micromachined Neuroprosthetic Device Insertion into the Brain
- Oh, Seung Jae; Smith, Karen L.; Bjornsson, Chris S.; Song, Jong Keun; Turner, James N.; Shain, William; Kim, Sung June
- Issue Date
- 2ne KAIST International Symposium on Frontier Issues in Nano-Bio-Information Technologies, Daejeon, Korea, October 27, 2003
- Insertion of prosthetic device is elicits reactive responses from both nervous tissue
and vasculature that prevent successful integration of these devices. Their chronic use is
limited due to glial encapsulation that electrically isolates devices from cellular
networks. We examined time-dependent changes of reactive responses in neocortex,
hippocampus, and thalamus using immunohistochemistry and confocal microscopy.
Results show dramatic differences in the magnitude of cellular response in different
brain regions and time-courses. These experiments will provide important new
information for the design of improved biomaterials and nano/micro-device to control
dynamic biological events in the central nervous system.