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Cerebral microbleeds are associated with nocturnal reverse dipping in hypertensive patients with ischemic stroke

DC Field Value Language
dc.contributor.authorKwon, Hyung-Min-
dc.contributor.authorLim, Jae-Sung-
dc.contributor.authorKim, Young Seo-
dc.contributor.authorMoon, Jangsup-
dc.contributor.authorPark, Hyeri-
dc.contributor.authorKim, Hyun Young-
dc.contributor.authorLim, Young-Hyo-
dc.contributor.authorNam, Hyunwoo-
dc.date.accessioned2014-02-07T01:02:28Z-
dc.date.available2014-02-07T01:02:28Z-
dc.date.issued2014-01-12-
dc.identifier.citationBMC Neurology Vol.4 No.8, pp. 1-7ko_KR
dc.identifier.urihttps://hdl.handle.net/10371/90853-
dc.description.abstractBackground
Abnormalities in nocturnal blood pressure dipping are well known for its relationship to cardiovascular diseases. Cerebral microbleeds are frequently observed in patients with hypertension and are known to be potent risk factors for stroke. However, there are scanty reports about the relationship between nocturnal dipping and cerebral microbleeds.

Methods
We recruited consecutive patients with both hypertension and ischemic stroke within 7 days after symptom onset, and those with cardioembolism were excluded. We applied 24-hour ambulatory blood pressure monitoring two weeks after stroke onset, and we used brain MRI to detect cerebral microbleeds. Various blood pressure parameters such as mean 24-hour blood pressure, awake/sleep blood pressure, and morning surge were compared between cerebral microbleeds (+) vs. (-) groups. Subjects were further classified according to nocturnal dipping status and were analyzed by logistic regression to determine its association with cerebral microbleeds with adjustment for age, gender, and cardiovascular risk factors.

Results
A total of 162 patients (100 males, age 65.33 ± 10.32 years) were included. Cerebral microbleeds were detected in 65 patients (40.1%). Most ambulatory blood pressure parameters except morning surge were significantly higher in those who had cerebral microbleeds. After adjusting for the confounding factors, the reverse dippers were prone to have cerebral microbleeds (odds ratio, 3.81; 95% confidential interval, 1.36-10.65; p-value = 0.01).

Conclusion
Cerebral microbleeds are independently associated with reverse dipping on ambulatory blood pressure monitoring in hypertensive stroke patients.
ko_KR
dc.description.sponsorshipThis study was supported by a grant from the Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea. (A101311)ko_KR
dc.language.isoenko_KR
dc.publisherBioMed Central Ltd.-
dc.subjectAmbulatory blood pressure monitoringko_KR
dc.subjectCerebral microbleedsko_KR
dc.subjectCerebrovascular diseaseko_KR
dc.subjectCerebral ischemiako_KR
dc.subjectHypertensionko_KR
dc.titleCerebral microbleeds are associated with nocturnal reverse dipping in hypertensive patients with ischemic strokeko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor권형민-
dc.contributor.AlternativeAuthor임재성-
dc.contributor.AlternativeAuthor김영서-
dc.contributor.AlternativeAuthor문장섭-
dc.contributor.AlternativeAuthor박혜리-
dc.contributor.AlternativeAuthor김현영-
dc.contributor.AlternativeAuthor임영효-
dc.contributor.AlternativeAuthor남현우-
dc.identifier.doi10.1186/1471-2377-14-8-
dc.citation.journaltitleBMC Neurology-
dc.language.rfc3066en-
dc.description.versionPeer Reviewed-
dc.rights.holderHyung-Min Kwon et al.; licensee BioMed Central Ltd.-
dc.date.updated2014-01-29T07:48:45Z-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Neurology (신경과학교실)Journal Papers (저널논문_신경과학교실)
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