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Multivariate analysis of prognostic factors in patients with pulmonary actinomycosis
DC Field | Value | Language |
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dc.contributor.author | Park, Ji Young | - |
dc.contributor.author | Lee, Taehoon | - |
dc.contributor.author | Lee, Hongyeul | - |
dc.contributor.author | Lim, Hyo-Jeong | - |
dc.contributor.author | Lee, Jinwoo | - |
dc.contributor.author | Park, Jong Sun | - |
dc.contributor.author | Cho, Young-Jae | - |
dc.contributor.author | Park, Young Sik | - |
dc.contributor.author | Lee, Chang-Hoon | - |
dc.contributor.author | Lee, Sang-Min | - |
dc.contributor.author | Yoon, Ho Il | - |
dc.contributor.author | Yim, Jae-Joon | - |
dc.contributor.author | Yoo, Chul-Gyu | - |
dc.contributor.author | Kim, Young Whan | - |
dc.contributor.author | Han, Sung Koo | - |
dc.contributor.author | Lee, Choon-Taek | - |
dc.contributor.author | Lee, Jae Ho | - |
dc.date.accessioned | 2014-02-07T01:10:27Z | - |
dc.date.available | 2014-02-07T01:10:27Z | - |
dc.date.issued | 2014-01-09 | - |
dc.identifier.citation | BMC Infectious Diseases Vol.14 No.10, pp.1-7 | ko_KR |
dc.identifier.uri | https://hdl.handle.net/10371/90854 | - |
dc.description.abstract | Background
There have been few studies of pulmonary actinomycosis, which is an uncommon anaerobic infection. Consequently, the optimal therapeutic regimen, appropriate duration of treatment, long-term prognosis, and factors predicting prognosis are not well established. Methods We retrospectively reviewed the medical records of histopathologically confirmed cases of pulmonary actinomycosis seen between November 2003 and December 2012. Results The study included 68 patients with a mean age of 58.4 ± 11.6 years. Of the 68, initial surgery was performed in 15 patients (22.1%), while the remaining 53 (77.9%) received antibiotic therapy initially. In the initial antibiotic group, 45/53 (84.9%) were cured without relapse (median antibiotic duration 5.3 months). 5/53 (9.4%) patients were refractory medically (median antibiotic duration 9.7 months), and 3/53 (5.7%) experienced a recurrence (median time to relapse 35.3 months). In the initial surgery group, 14/15 (93.3%) were cured and treatment failure occurred in one (6.7%). In the multivariate analysis, the absence of an antibiotic response at 1 month was the only independent factor associated with a poor treatment outcome, with an adjusted odds ratio of 49.2 (95% CI, 3.34–724.30). There was no significant difference in treatment outcome based on the size of the parenchymal lesion, comorbidities, whether intravenous antibiotics were used, antibiotic therapy duration, or whether the initial treatment was surgical. Conclusions Antibiotic treatment with or without surgery was effective for treatment of pulmonary actinomycosis. Nevertheless, treatment failure or recurrence occurred in a considerable proportion of patients, especially those resistant to the initial antibiotic treatment. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BioMed Central Ltd. | ko_KR |
dc.subject | Actinomycosis | ko_KR |
dc.subject | Anti-bacterial agents | ko_KR |
dc.subject | Treatment outcome | ko_KR |
dc.subject | Prognostic factors | ko_KR |
dc.subject | Pulmonary | ko_KR |
dc.title | Multivariate analysis of prognostic factors in patients with pulmonary actinomycosis | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 박지영 | - |
dc.contributor.AlternativeAuthor | 이태훈 | - |
dc.contributor.AlternativeAuthor | 이홍열 | - |
dc.contributor.AlternativeAuthor | 임효정 | - |
dc.contributor.AlternativeAuthor | 이진우 | - |
dc.contributor.AlternativeAuthor | 박종선 | - |
dc.contributor.AlternativeAuthor | 조영재 | - |
dc.contributor.AlternativeAuthor | 박영식 | - |
dc.contributor.AlternativeAuthor | 이창훈 | - |
dc.contributor.AlternativeAuthor | 이상민 | - |
dc.contributor.AlternativeAuthor | 윤호일 | - |
dc.contributor.AlternativeAuthor | 임재준 | - |
dc.contributor.AlternativeAuthor | 유철규 | - |
dc.contributor.AlternativeAuthor | 김영완 | - |
dc.contributor.AlternativeAuthor | 한성구 | - |
dc.contributor.AlternativeAuthor | 이춘택 | - |
dc.contributor.AlternativeAuthor | 이재호 | - |
dc.identifier.doi | 10.1186/1471-2334-14-10 | - |
dc.citation.journaltitle | BMC Infectious Diseases | - |
dc.language.rfc3066 | en | - |
dc.description.version | Peer Reviewed | - |
dc.rights.holder | Ji Young Park et al.; licensee BioMed Central Ltd. | - |
dc.date.updated | 2014-01-29T07:49:20Z | - |
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