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Effects of porous beta-tricalcium phosphate-based ceramics used as an E-coli-derived rhBMP-2 carrier for bone regeneration
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Jae Hyup | - |
dc.contributor.author | Ryu, Mi Young | - |
dc.contributor.author | Baek, Hae-Ri | - |
dc.contributor.author | Lee, Kyung Mee | - |
dc.contributor.author | Seo, Jun-Hyuk | - |
dc.contributor.author | Lee, Hyun-Kyung | - |
dc.contributor.author | Ryu, Hyun-Seung | - |
dc.creator | 이재협 | - |
dc.date.accessioned | 2014-02-24T00:26:30Z | - |
dc.date.available | 2014-02-24T00:26:30Z | - |
dc.date.issued | 2013-09 | - |
dc.identifier.citation | Journal of Materials Science: Materials in Medicine Vol.24 No.9, pp. 2117-2127 | - |
dc.identifier.issn | 0957-4530 (print) | - |
dc.identifier.issn | 1573-4838 (online) | - |
dc.identifier.uri | https://hdl.handle.net/10371/90954 | - |
dc.description.abstract | Recombinant human bone morphogenetic protein-2 (rhBMP-2) requires carriers for clinical effectiveness. In this study, whether porous beta-tricalcium phosphate (beta-TCP)-based ceramics are ideal carriers for rhBMP-2 was investigated. Hydroxyapatite (HA), beta-TCP, TCP/HA (80 %/20 %), HA with rhBMP-2, TCP with rhBMP-2, and TCP/HA (80 %/20 %) with rhBMP-2 were manufactured by a sponge method with a pore size of 300 mu m or more and macro-porosity of 83 %. The alkaline phosphatase (ALP) activity and ALP expression of the cells with 100 % beta-TCP granules were more increased than the those of cells with 100 % HA and TCP/HA (80 %/20 %) at the baseline or when treated with 15 ng/ml of rhBMP-2. In an SD rat calvarial defect model, new bone formation was evidently shown in the TCP 100 %-rhBMP-2 and TCP/HA (80 %/20 %)-rhBMP-2 groups, showing that the most affected area was filled with newly-formed bone, that the percent bone volume and trabecular number were larger when compared to the groups without rhBMP-2 treatment at both 4 and 8 weeks after surgery using micro-CT and histology. Porous TCP-based ceramic granules enhanced the osteoblastic differentiation in the hMSC system when treated with 15 ng/ml of rhBMP-2 and accelerated bone-healing by trabecular number in a rat calvarial defect model. Thus, in this study it was proposed that TCP-based ceramics might be useful carriers of rhBMP-2. | en |
dc.description.sponsorship | This study was supported by a Grant-in-Aid
from the Korean Ministry of Knowledge Economy/KEIT (No.10033623). | - |
dc.language.iso | en | en |
dc.publisher | Springer US | en |
dc.subject | 복합학 | en |
dc.title | Effects of porous beta-tricalcium phosphate-based ceramics used as an E-coli-derived rhBMP-2 carrier for bone regeneration | en |
dc.type | Article | - |
dc.author.alternative | 이재협 | - |
dc.author.alternative | 류미영 | - |
dc.author.alternative | 백해리 | - |
dc.author.alternative | 이경미 | - |
dc.author.alternative | 서준혁 | - |
dc.author.alternative | 이현경 | - |
dc.author.alternative | 류현승 | - |
dc.identifier.doi | 10.1007/s10856-013-4967-5 | - |
dc.citation.journaltitle | Journal of Materials Science: Materials in Medicine | - |
dc.description.srnd | OAIID:oai:osos.snu.ac.kr:snu2013-01/102/0000007273/8 | - |
dc.description.srnd | SEQ:8 | - |
dc.description.srnd | PERF_CD:SNU2013-01 | - |
dc.description.srnd | EVAL_ITEM_CD:102 | - |
dc.description.srnd | USER_ID:0000007273 | - |
dc.description.srnd | ADJUST_YN:Y | - |
dc.description.srnd | EMP_ID:A077517 | - |
dc.description.srnd | DEPT_CD:801 | - |
dc.description.srnd | CITE_RATE:2.141 | - |
dc.description.srnd | FILENAME:첨부된 내역이 없습니다. | - |
dc.description.srnd | DEPT_NM:의학과 | - |
dc.description.srnd | EMAIL:spinelee@snu.ac.kr | - |
dc.description.srnd | SCOPUS_YN:Y | - |
dc.description.srnd | CONFIRM:Y | - |
dc.identifier.srnd | 2013-01/102/0000007273/8 | - |
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