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A study on the prognostic value of clinical and surgical features of dermatofibrosarcoma protuberans in Korean patients
DC Field | Value | Language |
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dc.contributor.author | Kim, M. | - |
dc.contributor.author | Huh, C. H. | - |
dc.contributor.author | Cho, K. H. | - |
dc.contributor.author | Cho, S. | - |
dc.creator | 조소연 | - |
dc.date.accessioned | 2014-03-12T00:41:28Z | - |
dc.date.available | 2014-03-12T00:41:28Z | - |
dc.date.issued | 2012-08 | - |
dc.identifier.citation | Journal of the European Academy of Dermatology and Venereology Vol.26 No.8, pp. 964-971 | - |
dc.identifier.issn | 0926-9959 (print) | - |
dc.identifier.issn | 1468-3083 (online) | - |
dc.identifier.uri | https://hdl.handle.net/10371/91053 | - |
dc.description.abstract | BACKGROUND : Dermatofibrosarcoma protuberans (DFSP) is a rare spindle cell tumour with locally aggressive characteristics. Only few studies on the epidemiology of DFSP in Asians have been reported.
OBJECTIVES : The purpose of the study was to evaluate the epidemiological and clinical characteristics of DFSP in Korean patients and determine the prognostic factors that affect disease-free survival. METHODS : We conducted a retrospective review of patients diagnosed with primary or recurrent DFSP between 2000 and 2009 at three Seoul National University Hospitals. Patient, tumour and treatment factors were analysed for local recurrence-free survival. RESULTS : We analysed data for 65 patients, of whom 36 (55.4%) were female. The mean age at disease onset was 34.4 years with 50% aged between 20 and 40 years. Involved sites were most often on the trunk (66.1%). Among the 65 patients, 60 patients underwent wide excision; seven patients (10.8%) experienced local recurrence during 3.6 years of follow-up. The recurrence-free survival was significantly related to the microscopic resection margins (P = 0.005), clinical presentation (P = 0.002) and frequency of recurrence (P = 0.014) in the univariate analysis. There were three cases with metastasis, two of whom died because of progression of the disease despite continuous chemotherapy with imatinib mesylate. CONCLUSIONS : We report the epidemiologic and clinical characteristics of DFSP in Korea. Patients with recurrent disease at presentation and frequent recurrence have a high risk of recurrence and metastasis, and therefore close observation is needed in these patients. | en |
dc.description.sponsorship | This study was supported in part by grant no. 0420100310 from Seoul National University Research fund. Part of this study was presented at EADC (Eastern Asia Dermatology Congress)2010. | - |
dc.language.iso | en | en |
dc.publisher | European Academy of Dermatology and Venereology | en |
dc.publisher | Blackwell Publishing | - |
dc.subject | 복합학 | en |
dc.title | A study on the prognostic value of clinical and surgical features of dermatofibrosarcoma protuberans in Korean patients | en |
dc.type | Article | - |
dc.author.alternative | 조소연 | - |
dc.identifier.doi | 10.1111/j.1468-3083.2011.04190.x | - |
dc.citation.journaltitle | Journal of the European Academy of Dermatology and Venereology | - |
dc.description.srnd | OAIID:oai:osos.snu.ac.kr:snu2012-01/102/2008000790/7 | - |
dc.description.srnd | SEQ:7 | - |
dc.description.srnd | PERF_CD:SNU2012-01 | - |
dc.description.srnd | EVAL_ITEM_CD:102 | - |
dc.description.srnd | USER_ID:2008000790 | - |
dc.description.srnd | ADJUST_YN:Y | - |
dc.description.srnd | EMP_ID:A079501 | - |
dc.description.srnd | DEPT_CD:801 | - |
dc.description.srnd | CITE_RATE:2.694 | - |
dc.description.srnd | FILENAME:dfsp jeadv.pdf | - |
dc.description.srnd | DEPT_NM:의학과 | - |
dc.description.srnd | EMAIL:sycho@snu.ac.kr | - |
dc.description.srnd | CONFIRM:Y | - |
dc.identifier.srnd | 2012-01/102/2008000790/7 | - |
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