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Intratumoral mast cell number is negatively correlated with tumor size and mitosis in dermatofibrosarcoma protuberans

Cited 5 time in Web of Science Cited 6 time in Scopus
Authors
Kim, Minji; Cho, Kwang Hyun; Lee, Jong Hee; Chang, Mee Soo; Cho, Soyun
Issue Date
2012-07
Publisher
John Wiley & Sons A/S
Citation
Experimental Dermatology Vol.21 No.7, pp. 559-561
Keywords
복합학c-kitdermatofibrosarcoma protuberansmast cellp-53smooth muscle actin
Abstract
Dermatofibrosarcoma protuberans (DFSP) is a rare cutaneous tumor with intermediate malignancy. The purpose of this study was to evaluate the utility of p53, smooth muscle actin (SMA) and c-kit as immunohistochemical markers and toluidine blue staining for mast cell that can correlate with the clinical outcome and clarify role of mast cells in pathogenesis of tumor. We analysed data for 32 lesions from 31 patients. Fibrosarcomatous type DFSP showed high immunoreactivity for SMA compared with other subtypes (P = 0.026). No differences in p53 immunoreactivity were observed between subtypes. None of tumor cells were immunoreactive with c-kit. The mast cell counts showed a negative correlation with mitosis and tumor size (P < 0.05), implying that mast cells do not have a causative primary role in tumorigenesis but rather play a secondary role.
ISSN
0906-6705 (print)
1600-0625 (online)
Language
English
URI
https://hdl.handle.net/10371/91055
DOI
https://doi.org/10.1111/j.1600-0625.2012.01530.x
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)Journal Papers (저널논문_의학과)
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