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Betaine Protects Against Rotenone-Induced Neurotoxicity in PC12 Cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Im, A-Rang | - |
dc.contributor.author | Kim, Young-Hwa | - |
dc.contributor.author | Uddin, Md. Romij | - |
dc.contributor.author | Chae, Sungwook | - |
dc.contributor.author | Lee, Hye Won | - |
dc.contributor.author | Kim, Yun Hee | - |
dc.contributor.author | Kim, Yeong Shik | - |
dc.contributor.author | Lee, Mi-Young | - |
dc.creator | 김영식 | - |
dc.date.accessioned | 2014-03-24T04:39:37Z | - |
dc.date.available | 2014-03-24T04:39:37Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2013-07 | - |
dc.identifier.citation | CELLULAR AND MOLECULAR NEUROBIOLOGY, Vol.33 No.5, pp.625-635 | - |
dc.identifier.issn | 0272-4340 | - |
dc.identifier.uri | https://hdl.handle.net/10371/91115 | - |
dc.description.abstract | Rotenone is an inhibitor of mitochondrial complex I-induced neurotoxicity in PC12 cells and has been widely studied to elucidate the pathogenesis of Parkinson's disease. We investigated the neuroprotective effects of betaine on rotenone-induced neurotoxicity in PC12 cells. Betaine inhibited rotenone-induced apoptosis in a dose-dependent manner, with cell viability increasing from 50 % with rotenone treatment alone to 71 % with rotenone plus 100-mu M betaine treatment. Flow cytometric analysis demonstrated cell death in the rotenone-treated cells to be over 50 %; the number of live cells increased with betaine pretreatment. Betaine pretreatment of PC12 cells attenuated rotenone-mediated mitochondrial dysfunction, including nuclear fragmentation, ATP depletion, mitochondrial membrane depolarization, caspase-3/7 activation, and reactive oxygen species production. Western blots demonstrated activation of caspase-3 and caspase-9, and their increased expression levels in rotenone-treated cells; betaine decreased caspase-3 and caspase-9 expression levels and suppressed their activation. Together, these results suggest that betaine may serve as a neuroprotective agent in the treatment of neurodegenerative diseases. | - |
dc.language | 영어 | - |
dc.language.iso | en | en |
dc.publisher | SPRINGER/PLENUM PUBLISHERS | - |
dc.subject | PARKINSONS-DISEASE | - |
dc.subject | DEATH | - |
dc.subject | MECHANISMS | - |
dc.subject | CASPASE-3 | - |
dc.subject | NUTRITION | - |
dc.subject | MODELS | - |
dc.subject | RATS | - |
dc.title | Betaine Protects Against Rotenone-Induced Neurotoxicity in PC12 Cells | - |
dc.type | Article | - |
dc.author.alternative | 임아랑 | - |
dc.author.alternative | 김영화 | - |
dc.author.alternative | 채성욱 | - |
dc.author.alternative | 이혜원 | - |
dc.author.alternative | 김윤희 | - |
dc.author.alternative | 김영식 | - |
dc.author.alternative | 이미영 | - |
dc.identifier.doi | 10.1007/s10571-013-9921-z | - |
dc.citation.journaltitle | CELLULAR AND MOLECULAR NEUROBIOLOGY | - |
dc.identifier.wosid | 000319746400004 | - |
dc.identifier.scopusid | 2-s2.0-84878718707 | - |
dc.description.srnd | OAIID:oai:osos.snu.ac.kr:snu2013-01/102/0000001731/21 | - |
dc.description.srnd | SEQ:21 | - |
dc.description.srnd | PERF_CD:SNU2013-01 | - |
dc.description.srnd | EVAL_ITEM_CD:102 | - |
dc.description.srnd | USER_ID:0000001731 | - |
dc.description.srnd | ADJUST_YN:N | - |
dc.description.srnd | EMP_ID:A000864 | - |
dc.description.srnd | DEPT_CD:371 | - |
dc.description.srnd | CITE_RATE:2.293 | - |
dc.description.srnd | FILENAME:betaine-arang.pdf | - |
dc.description.srnd | DEPT_NM:제약학과 | - |
dc.description.srnd | EMAIL:kims@snu.ac.kr | - |
dc.description.srnd | SCOPUS_YN:Y | - |
dc.description.srnd | CONFIRM:Y | - |
dc.citation.endpage | 635 | - |
dc.citation.number | 5 | - |
dc.citation.startpage | 625 | - |
dc.citation.volume | 33 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, Yeong Shik | - |
dc.identifier.srnd | 2013-01/102/0000001731/21 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | PARKINSONS-DISEASE | - |
dc.subject.keywordPlus | DEATH | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | CASPASE-3 | - |
dc.subject.keywordPlus | NUTRITION | - |
dc.subject.keywordPlus | MODELS | - |
dc.subject.keywordPlus | RATS | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.subject.keywordAuthor | Betaine | - |
dc.subject.keywordAuthor | Mitochondrial dysfunction | - |
dc.subject.keywordAuthor | Neuroprotection | - |
dc.subject.keywordAuthor | Rotenone | - |
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