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Betaine Protects Against Rotenone-Induced Neurotoxicity in PC12 Cells

DC Field Value Language
dc.contributor.authorIm, A-Rang-
dc.contributor.authorKim, Young-Hwa-
dc.contributor.authorUddin, Md. Romij-
dc.contributor.authorChae, Sungwook-
dc.contributor.authorLee, Hye Won-
dc.contributor.authorKim, Yun Hee-
dc.contributor.authorKim, Yeong Shik-
dc.contributor.authorLee, Mi-Young-
dc.creator김영식-
dc.date.accessioned2014-03-24T04:39:37Z-
dc.date.available2014-03-24T04:39:37Z-
dc.date.created2017-11-15-
dc.date.issued2013-07-
dc.identifier.citationCELLULAR AND MOLECULAR NEUROBIOLOGY, Vol.33 No.5, pp.625-635-
dc.identifier.issn0272-4340-
dc.identifier.urihttps://hdl.handle.net/10371/91115-
dc.description.abstractRotenone is an inhibitor of mitochondrial complex I-induced neurotoxicity in PC12 cells and has been widely studied to elucidate the pathogenesis of Parkinson's disease. We investigated the neuroprotective effects of betaine on rotenone-induced neurotoxicity in PC12 cells. Betaine inhibited rotenone-induced apoptosis in a dose-dependent manner, with cell viability increasing from 50 % with rotenone treatment alone to 71 % with rotenone plus 100-mu M betaine treatment. Flow cytometric analysis demonstrated cell death in the rotenone-treated cells to be over 50 %; the number of live cells increased with betaine pretreatment. Betaine pretreatment of PC12 cells attenuated rotenone-mediated mitochondrial dysfunction, including nuclear fragmentation, ATP depletion, mitochondrial membrane depolarization, caspase-3/7 activation, and reactive oxygen species production. Western blots demonstrated activation of caspase-3 and caspase-9, and their increased expression levels in rotenone-treated cells; betaine decreased caspase-3 and caspase-9 expression levels and suppressed their activation. Together, these results suggest that betaine may serve as a neuroprotective agent in the treatment of neurodegenerative diseases.-
dc.language영어-
dc.language.isoenen
dc.publisherSPRINGER/PLENUM PUBLISHERS-
dc.subjectPARKINSONS-DISEASE-
dc.subjectDEATH-
dc.subjectMECHANISMS-
dc.subjectCASPASE-3-
dc.subjectNUTRITION-
dc.subjectMODELS-
dc.subjectRATS-
dc.titleBetaine Protects Against Rotenone-Induced Neurotoxicity in PC12 Cells-
dc.typeArticle-
dc.author.alternative임아랑-
dc.author.alternative김영화-
dc.author.alternative채성욱-
dc.author.alternative이혜원-
dc.author.alternative김윤희-
dc.author.alternative김영식-
dc.author.alternative이미영-
dc.identifier.doi10.1007/s10571-013-9921-z-
dc.citation.journaltitleCELLULAR AND MOLECULAR NEUROBIOLOGY-
dc.identifier.wosid000319746400004-
dc.identifier.scopusid2-s2.0-84878718707-
dc.description.srndOAIID:oai:osos.snu.ac.kr:snu2013-01/102/0000001731/21-
dc.description.srndSEQ:21-
dc.description.srndPERF_CD:SNU2013-01-
dc.description.srndEVAL_ITEM_CD:102-
dc.description.srndUSER_ID:0000001731-
dc.description.srndADJUST_YN:N-
dc.description.srndEMP_ID:A000864-
dc.description.srndDEPT_CD:371-
dc.description.srndCITE_RATE:2.293-
dc.description.srndFILENAME:betaine-arang.pdf-
dc.description.srndDEPT_NM:제약학과-
dc.description.srndEMAIL:kims@snu.ac.kr-
dc.description.srndSCOPUS_YN:Y-
dc.description.srndCONFIRM:Y-
dc.citation.endpage635-
dc.citation.number5-
dc.citation.startpage625-
dc.citation.volume33-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorKim, Yeong Shik-
dc.identifier.srnd2013-01/102/0000001731/21-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusPARKINSONS-DISEASE-
dc.subject.keywordPlusDEATH-
dc.subject.keywordPlusMECHANISMS-
dc.subject.keywordPlusCASPASE-3-
dc.subject.keywordPlusNUTRITION-
dc.subject.keywordPlusMODELS-
dc.subject.keywordPlusRATS-
dc.subject.keywordAuthorApoptosis-
dc.subject.keywordAuthorBetaine-
dc.subject.keywordAuthorMitochondrial dysfunction-
dc.subject.keywordAuthorNeuroprotection-
dc.subject.keywordAuthorRotenone-
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