Publications
Detailed Information
Chemical inhibition of prometastatic lysyl-tRNA synthetase-laminin receptor interaction
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Dae Gyu | - |
dc.contributor.author | Lee, Jin Young | - |
dc.contributor.author | Kwon, Nam Hoon | - |
dc.contributor.author | Fang, Pengfei | - |
dc.contributor.author | Zhang, Qian | - |
dc.contributor.author | Wang, Jing | - |
dc.contributor.author | Young, Nicolas L | - |
dc.contributor.author | Guo, Min | - |
dc.contributor.author | Cho, Hye Young | - |
dc.contributor.author | Mushtaq, Ameeq Ul | - |
dc.contributor.author | Jeon, Young Ho | - |
dc.contributor.author | Choi, Jin Woo | - |
dc.contributor.author | Han, Jung Min | - |
dc.contributor.author | Kang, Ho Woong | - |
dc.contributor.author | Joo, Jae Eun | - |
dc.contributor.author | Hur, Youn | - |
dc.contributor.author | Kang, Wonyoung | - |
dc.contributor.author | Yang, Heekyoung | - |
dc.contributor.author | Nam, Do-Hyun | - |
dc.contributor.author | Lee, Mi-Sook | - |
dc.contributor.author | Lee, Jung Weon | - |
dc.contributor.author | Kim, Eun-Sook | - |
dc.contributor.author | Moon, Aree | - |
dc.contributor.author | Kim, Kibom | - |
dc.contributor.author | Kim, Doyeun | - |
dc.contributor.author | Kang, Eun Joo | - |
dc.contributor.author | Moon, Youngji | - |
dc.contributor.author | Rhee, Kyung Hee | - |
dc.contributor.author | Han, Byung Woo | - |
dc.contributor.author | Yang, Jee Sun | - |
dc.contributor.author | Han, Gyoonhee | - |
dc.contributor.author | Yang, Won Suk | - |
dc.contributor.author | Lee, Cheolju | - |
dc.contributor.author | Wang, Ming-Wei | - |
dc.contributor.author | Kim, Sunghoon | - |
dc.creator | 한병우 | - |
dc.date.accessioned | 2014-04-01T02:16:58Z | - |
dc.date.available | 2014-04-01T02:16:58Z | - |
dc.date.issued | 2014-01 | - |
dc.identifier.citation | Nature Chemical Biology Vol.10 No.1, pp. 29-34 | - |
dc.identifier.issn | 1552-4450 (print) | - |
dc.identifier.issn | 1552-4469 (print) | - |
dc.identifier.uri | https://hdl.handle.net/10371/91277 | - |
dc.description.abstract | Lysyl-tRNA synthetase (KRS), a protein synthesis enzyme in the cytosol, relocates to the plasma membrane after a laminin signal and stabilizes a 67-kDa laminin receptor (67LR) that is implicated in cancer metastasis; however, its potential as an antimetastatic therapeutic target has not been explored. We found that the small compound BC-K-YH16899, which binds KRS, impinged on the interaction of KRS with 67LR and suppressed metastasis in three different mouse models. The compound inhibited the KRS-67LR interaction in two ways. First, it directly blocked the association between KRS and 67LR. Second, it suppressed the dynamic movement of the N-terminal extension of KRS and reduced membrane localization of KRS. However, it did not affect the catalytic activity of KRS. Our results suggest that specific modulation of a cancer-related KRS-67LR interaction may offer a way to control metastasis while avoiding the toxicities associated with inhibition of the normal functions of KRS. | en |
dc.description.sponsorship | This work was supported by the Global Frontier Project (grants NRF-M1AXA002-2010-0029785 (S.K.), NRF-M1AXA002-2010-0029765 (Y.H.J.), NRF-2012M3A6A4054271 (J.W.L.) and NRF- 2012-054237 (B.W.H.)), the World Class University (grant R31-2008-000-10086-0 (G.H.)), the Proteogenomic Research Program (2012M3A9B9036679 (C.L.)) and by the National Research Foundation funded by the Ministry of Education, Science and Technology of Korea (grant ROA-2012-0006262 (A.M.)). This study was also funded by the Ministry for Health and Welfare Affairs of Korea through the Korea Healthcare Technology Research and Development Project (A092255 (D.-H.N.)) and by a grant from Gyeonggi Research Development Program (S.K.). This work was supported in part by grants from the US National Institutes of Health (GM100136 (M.G.)); the US National Science Foundation Division of Materials Research through DMR-11-57490 (A.G. Marshall, Florida State University); by the state of Florida (M.G.) and by a Kimmel Scholar Award for Cancer Research (M.G.). We appreciate A.G. Marshall for supporting the HDX-MS program and facility, M.-S. Seok (Korea University) for the preparation of the nanodisc and S.W. Lee (Sungkyunkwan University) for X-ray analysis. | - |
dc.language.iso | en | en |
dc.publisher | Nature Publishing Group | en |
dc.subject | 복합학 | en |
dc.title | Chemical inhibition of prometastatic lysyl-tRNA synthetase-laminin receptor interaction | en |
dc.type | Article | - |
dc.author.alternative | 김대규 | - |
dc.author.alternative | 이진영 | - |
dc.author.alternative | 권남훈 | - |
dc.author.alternative | 조혜영 | - |
dc.author.alternative | 전영호 | - |
dc.author.alternative | 최진우 | - |
dc.author.alternative | 한정민 | - |
dc.author.alternative | 강호웅 | - |
dc.author.alternative | 주재은 | - |
dc.author.alternative | 허 연 | - |
dc.author.alternative | 강원영 | - |
dc.author.alternative | 양희경 | - |
dc.author.alternative | 남도현 | - |
dc.author.alternative | 이미숙 | - |
dc.author.alternative | 이정원 | - |
dc.author.alternative | 김은숙 | - |
dc.author.alternative | 문아리 | - |
dc.author.alternative | 김기범 | - |
dc.author.alternative | 김도연 | - |
dc.author.alternative | 강은주 | - |
dc.author.alternative | 문영지 | - |
dc.author.alternative | 이경희 | - |
dc.author.alternative | 한병우 | - |
dc.author.alternative | 양지선 | - |
dc.author.alternative | 한권희 | - |
dc.author.alternative | 양원석 | - |
dc.author.alternative | 이철주 | - |
dc.author.alternative | 김성훈 | - |
dc.identifier.doi | 10.1038/nchembio.1381 | - |
dc.citation.journaltitle | Nature Chemical Biology | - |
dc.description.srnd | OAIID:oai:osos.snu.ac.kr:snu2014-01/102/0000012460/1 | - |
dc.description.srnd | SEQ:1 | - |
dc.description.srnd | PERF_CD:SNU2014-01 | - |
dc.description.srnd | EVAL_ITEM_CD:102 | - |
dc.description.srnd | USER_ID:0000012460 | - |
dc.description.srnd | ADJUST_YN:Y | - |
dc.description.srnd | EMP_ID:A078106 | - |
dc.description.srnd | DEPT_CD:375 | - |
dc.description.srnd | CITE_RATE:12.948 | - |
dc.description.srnd | FILENAME:첨부된 내역이 없습니다. | - |
dc.description.srnd | DEPT_NM:약학과 | - |
dc.description.srnd | EMAIL:bwhan@snu.ac.kr | - |
dc.description.srnd | SCOPUS_YN:Y | - |
dc.description.srnd | CONFIRM:Y | - |
dc.identifier.srnd | 2014-01/102/0000012460/1 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.