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The role of lysyl oxidase-like 2 in the odontogenic differentiation of human dental pulp stem cells

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dc.contributor.authorKim, Joo-Hyun-
dc.contributor.authorLee, Eun-Hyang-
dc.contributor.authorPark, Hye-jeong-
dc.contributor.authorPark, Eui-Kyun-
dc.contributor.authorKwon, Tae-Geon-
dc.contributor.authorShin, Hong-In-
dc.contributor.authorCho, Je-Yoel-
dc.creator조제열-
dc.date.accessioned2014-05-01T08:12:28Z-
dc.date.available2014-05-01T08:12:28Z-
dc.date.issued2013-01-
dc.identifier.citationMolecules and Cells, Vol.35 No.6, pp. 543-549-
dc.identifier.issn1016-8478-
dc.identifier.urihttps://hdl.handle.net/10371/91633-
dc.description.abstractAdult human dental pulp stem cells (hDPSCs) are a unique population of precursor cells those are isolated from postnatal dental pulp and have the ability to differentiate into a variety of cell types utilized for the formation of a reparative dentin-like complex. Using LC-MS/MS proteomics approaches, we identified the proteins secreted from the differentiating hDPSCs in mineralization media. Lysyl oxidase-like 2 (LOXL2) was identified as a protein that was down-regulated in the hDPSCs that differentiate into odontoblast-like cells. The role of LOXL2 has not been studied in dental pulp stem cells. LOXL2 mRNA levels were reduced in differentiating hDPSCs, whereas the levels of other LOX family members including LOX, LOXL1, LOXL3, and LOXL4, are increased. The protein expression and secretion levels of LOXL2 were also decreased during odontogenic differentiation. Recombinant LOXL2 protein treatment to hDPSCs resulted in a dose-dependent decrease in the early differentiation and the mineralization accompanying with the lower levels of odontogenic markers such as DSPP, DMP-1 and ALP. These results suggest that LOXL2 has a negative effect on the differentiation of hDPSCs and blocking LOXL2 can promote the hDPSC differentiation to odontoblasts.-
dc.language.isoenen
dc.publisherSpringer Verlagen
dc.subject복합학en
dc.subjecthuman dental pulp stem cells-
dc.subjectlysyl oxidase-like 2-
dc.subjectodontogenic differentiation-
dc.titleThe role of lysyl oxidase-like 2 in the odontogenic differentiation of human dental pulp stem cellsen
dc.typeArticle-
dc.contributor.AlternativeAuthor김주현-
dc.contributor.AlternativeAuthor이은향-
dc.contributor.AlternativeAuthor박혜정-
dc.contributor.AlternativeAuthor박의균-
dc.contributor.AlternativeAuthor권태건-
dc.contributor.AlternativeAuthor신홍인-
dc.contributor.AlternativeAuthor조제열-
dc.identifier.doi10.1007/s10059-013-0080-3-
dc.description.srndOAIID:oai:osos.snu.ac.kr:snu2013-01/102/2008006987/6-
dc.description.srndSEQ:6-
dc.description.srndPERF_CD:SNU2013-01-
dc.description.srndEVAL_ITEM_CD:102-
dc.description.srndUSER_ID:2008006987-
dc.description.srndADJUST_YN:N-
dc.description.srndEMP_ID:A078834-
dc.description.srndDEPT_CD:551-
dc.description.srndCITE_RATE:2.21-
dc.description.srndFILENAME:the role of lysyl oxidase like 2 in.pdf-
dc.description.srndDEPT_NM:수의학과-
dc.description.srndEMAIL:jeycho@snu.ac.kr-
dc.description.srndSCOPUS_YN:Y-
dc.description.srndCONFIRM:Y-
dc.identifier.srnd2013-01/102/2008006987/6-
Appears in Collections:
College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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