Browse

Structure-based design and biochemical evaluation of sulfanilamide derivatives as hepatitis B virus capsid assembly inhibitors

Cited 9 time in Web of Science Cited 11 time in Scopus
Authors
Cho, Min-Hyung; Song, Jin-Su; Kim, Hie-Joon; Park, Sung-Gyoo; Jung, Guhung
Issue Date
2013-10
Publisher
TAYLOR & FRANCIS
Citation
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol.28 No.5, pp. 916-925
Keywords
자연과학Capsid assembly inhibitionhepatitis B viruscp149structure simulationrational drug design
Abstract
Virus capsid structure is essential in virion maturation and durability, so disrupting capsid assembly could be an effective way to reduce virion count and cure viral diseases. However, currently there is no known antiviral which affects capsid inhibition, and only a small number of assembly inhibitors were experimentally successful. In this present study, we aimed to find hepatitis B virus (HBV) capsid assembly inhibitor which binds to the HBV core protein and changes protein conformation. Several candidate molecules were found to bind to certain structure in core protein with high specificity. Furthermore, these molecules significantly changed the protein conformation and reduced assembly affinity of core protein, leading to decrease of the number of assembled capsid or virion, both in vitro and in vivo. In addition, prediction also suggests that improvements in inhibition efficiency could be possible by changing functional groups and ring structures.
ISSN
1475-6366
Language
English
URI
http://hdl.handle.net/10371/91634
DOI
https://doi.org/10.3109/14756366.2012.694879
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Natural Sciences (자연과학대학)Dept. of Biological Sciences (생명과학부)Journal Papers (저널논문_생명과학부)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse