Browse

Independent component analysis of generalized spike-and-wave discharges: primary versus secondary bilateral synchrony

DC Field Value Language
dc.contributor.authorJung, Ki-Young-
dc.contributor.authorKim, Jae-Moon-
dc.contributor.authorKim, Dong Wook-
dc.contributor.authorChung, Chin-Sang-
dc.creator정기영-
dc.date.accessioned2014-05-15T04:22:51Z-
dc.date.available2014-05-15T04:22:51Z-
dc.date.issued2005-04-
dc.identifier.citationClinical Neurophysiology, Vol.116 No.4, pp. 913-919-
dc.identifier.issn1388-2457-
dc.identifier.urihttps://hdl.handle.net/10371/91776-
dc.description.abstractObjective: To differentiate between primary and secondary bilateral synchrony (PBS and SBS, respectively) in generalized spike-and-wave discharges (GSWD), we applied independent component analysis (ICA) to GSWD, and analyzed the characteristic patterns of independent components.Methods: EEGs from 19 patients with GSWD (9 PBS patients, 10 SBS patients) were studied. Thirty GSWD epochs were selected and concatenated to construct an EEG data matrix that was subjected to ICA. Selected independent components were localized by mapping them on a spherical model of the head by means of brain electrical source analysis (BESA) to define dipole sources.Results: Epileptic components of GSWD were clearly separated by the ICA algorithm in all patients. Between one and three components per patient were responsible, for GSWD. In PBS patients, 70.6% of the independent components had dipole sources within the dorsolateral frontal region, and 56.5% of the independent components in SBS patients were within the medial frontal region (P=0.012). The orientation of all of the independent components in PBS patients was radial, whereas 47.8% of the independent components in SBS patients were tangential; this difference was statistically significant (P=0.001).Conclusions: Spatiotemporal decomposition of GSWD by using ICA might be helpful for differentiating SBS from PBS.Significance: The localization of the dipole sources of the independent components may provide insight into the pathophysiological origins of GSWD.en
dc.language.isoenen
dc.publisherElsevieren
dc.subject공학en
dc.subjectGeneralized spike-
dc.subjectwave discharge-
dc.subjectIndependent component analysis-
dc.subjectPrimary bilateral synchrony-
dc.subjectSecondary bilateral synchrony-
dc.titleIndependent component analysis of generalized spike-and-wave discharges: primary versus secondary bilateral synchronyen
dc.typeArticle-
dc.contributor.AlternativeAuthor정기영-
dc.contributor.AlternativeAuthor김재문-
dc.contributor.AlternativeAuthor김동욱-
dc.contributor.AlternativeAuthor정진상-
dc.identifier.doi10.1016/j.clinph.2004.11.023-
dc.description.srndOAIID:oai:osos.snu.ac.kr:snu2005-01/102/2014017262/1-
dc.description.srndSEQ:1-
dc.description.srndPERF_CD:SNU2005-01-
dc.description.srndEVAL_ITEM_CD:102-
dc.description.srndUSER_ID:2014017262-
dc.description.srndADJUST_YN:Y-
dc.description.srndEMP_ID:A079623-
dc.description.srndDEPT_CD:801-
dc.description.srndCITE_RATE:2.64-
dc.description.srndDEPT_NM:의학과-
dc.description.srndSCOPUS_YN:Y-
dc.description.srndCONFIRM:Y-
dc.identifier.srnd2005-01/102/2014017262/1-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Neurology (신경과학교실)Journal Papers (저널논문_신경과학교실)
Files in This Item:
There are no files associated with this item.
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse