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Reduced Frontal P3a Amplitude in Migraine Patients during the Pain-Free Period

Cited 7 time in Web of Science Cited 7 time in Scopus
Authors
Koo, Yong Seo; Ko, Deokwon; Lee, Gwan-Taek; Oh, Kyungmi; Kim, Myung-Sun; Kim, Kyung Hwan; Im, Chang-Hwan; Jung, Ki-Young
Issue Date
2013-07
Publisher
Korean Neurological Association
Citation
Journal of Clinical Neurology, Vol.9 No.3, pp. 43-50
Keywords
의약학migrainecognitive functionattentionfrontalevent-related potentialsP3a
Abstract
Background and Purpose Neuropsychological and neuroimaging studies both suggest that frontal lobe dysfunction is present in migraineurs. Since P3a abnormalities manifest in other diseases associated with attention problems, such as attention deficit hyperactivity disorder, we hypothesized that migraine patients have P3a abnormalities, particularly in the frontal region. Methods Event-related potentials were measured using a passive auditory oddball paradigm in 16 female migraineurs (aged 22.9 +/- 2.0 years, mean +/- SD) during the interictal period and in 16 age-matched healthy females (22.6 +/- 2.0 years). The amplitudes and latencies were analyzed independently using repeated-measures analysis of variance. Nonparametric statistical testing using a cluster-level randomization method was performed to localize the abnormalities. Results The mean P3a amplitude at frontal areas during the third trials was significantly lower in migraineurs (1.06 mu V) than in controls (1.69 mu V, p=0.026). P3a amplitudes were negatively correlated with the duration of the migraine history (r=-0.618, p=0.014). Cluster-based nonparametric statistical analysis showed that the amplitudes over left frontal areas were significantly lower in migraine patients than in controls. Conclusions A reduced P3a amplitude of migraineurs reflects attentional deficits and frontal dysfunction. The negative correlation between P3a amplitude and the duration of the migraine history suggests that attentional deficits and frontal dysfunction are either the cause or the result of headache.
ISSN
1738-6586
Language
English
URI
https://hdl.handle.net/10371/91781
DOI
https://doi.org/10.3988/jcn.2013.9.1.43
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Neurology (신경과학교실)Journal Papers (저널논문_신경과학교실)
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