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Multichannel surface electrodes increase the sensitivity of diagnosis of neuropathy in diabetic patients

Cited 3 time in Web of Science Cited 3 time in Scopus
Authors
Koo, Yong Seo; Jung, Ki-Young; Lee, Sang-Hoon; Cho, Charles S.; Yang, Kyung-Sook; Jang, Jae Hong; Kim, Byung-Jo
Issue Date
2013-10
Publisher
Elsevier
Citation
Journal of Electromyography and Kinesiology, Vol.23 No.5, pp. 1057-1064
Keywords
의약학Multichannel electrodeDiabetic neuropathiesEarly diagnosisCompound muscle action potentialsNerve conduction studyNeural conduction
Abstract
This prospective study investigated the diagnostic sensitivity of a novel multichannel surface electrode for detecting electrophysiologic changes in symptomatic diabetic neuropathy. We recruited healthy subjects without neuropathic complaints and diabetic patients with distal symmetric sensory symptoms who had normal nerve conduction studies (NCS). Eight compound muscle action potentials (CMAPs) were recorded using a multichannel electrode from each subject's abductor pollicis brevis muscle by stimulating the median nerve at the wrist. Latency-and amplitude-related variables were obtained and analyzed to compare the two groups. We used the Classification and Regression Tree (CART# algorithm to determine the cut-off values for selected predictors of diabetic neuropathy. All of the variables related to CMAP latency showed statistically significant differences between the median values for the diabetic group and the healthy control group. For example, the median value of the maximum latency and standard deviation of the eight CMAP onset latencies in diabetic patients #3.82 ms and 0.15 ms, respectively# were significantly larger than those in controls #3.26 ms and p < 0.001; 0.09 ms and p < 0.001, respectively#. The CART analysis revealed that these variables were the most sensitive and specific variables for discriminating between patients with diabetic neuropathy and normal subjects. The multichannel surface electrode demonstrated both high sensitivity and specificity in detecting neurophysiologic abnormality of diabetic neuropathy, even when conventional NCS did not detect the abnormality.
ISSN
1050-6411
Language
English
URI
https://hdl.handle.net/10371/91792
DOI
https://doi.org/10.1016/j.jelekin.2013.07.003
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Neurology (신경과학교실)Journal Papers (저널논문_신경과학교실)
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