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Low resolution electromagnetic tomography analysis of ictal EEG patterns in mesial temporal lobe epilepsy with hippocampal sclerosis

Cited 6 time in Web of Science Cited 5 time in Scopus
Authors
Lee, Eun Mi; Shon, Young-Min; Jung, Ki-Young; Lee, Sang-Ahm; Yum, Myung-Kul; Lee, Il Keun; Kim, Ji-Hyun; Park, Ki-Jong; Kwon, Oh-Young; Kang, Joong Koo
Issue Date
2009-10
Publisher
Elsevier
Citation
Clinical Neurophysiology, Vol.120 No.10, pp. 1797-1805
Keywords
의약학Mesial temporal lobe epilepsyHippocampal sclerosisSource localizationInitial ictal dischargeLORETA
Abstract
Objective: To investigate the difference in the spatial distribution of scalp initial ictal discharge (IID) patterns in mesial temporal lobe epilepsy with hippocampal sclerosis (HS-MTLE). Methods: Scalp ictal EEG data in 22 seizure-free patients after temporal lobectomy with amygdalo-hippocampectomy were classified as follows: a regular 5-9 Hz rhythm with a restricted temporal/subtemporal distribution (type 1, 11 patients), or an irregular 2-5 Hz rhythm with a widespread fronto-temporal distribution (type 2, 11 patients). EEG data were fragmented into segments of 1.28 s, both at ictal onset and at baseline. The LORETA solution of three frequency bands was compared between ictal and baseline using statistical non-parametric mapping (p < 0.01). Results: The LORETA solution of 5-9 Hz in type 2 had wider cortical activity in the ipsilateral fronto-temporal area, compared to type 1 with activation of the ipsilateral focal mesial and lateral temporal regions. The LORETA solution of 10-13 Hz in both types showed increased activity in the fronto-temporal area, which was wider in type 2 than type 1. Increased cortical activity of <5 Hz was not observed in type 1, whereas increased cortical activity was observed in the bilateral anterior frontal area in type 2. Conclusions: The cortical source distribution in HS-MTLE may depend on scalp IID frequency. The neural generators of 5-13 Hz may be important for the formation of the ictal onset zone in both ictal patterns. Significance: Spatial distributions in HS-MTLE patients differ with scalp IID frequency.
ISSN
1388-2457
Language
English
URI
http://hdl.handle.net/10371/91795
DOI
https://doi.org/10.1016/j.clinph.2009.08.003
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Neurology (신경과학교실)Journal Papers (저널논문_신경과학교실)
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