Publications
Detailed Information
Cognitive effects of topiramate revealed by standardised low-resolution brain electromagnetic tomography (sLORETA) of event-related potentials
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jung, Ki-Young | - |
dc.contributor.author | Cho, Jae-Wook | - |
dc.contributor.author | Joo, Eun Yeon | - |
dc.contributor.author | Kim, Sun Hwa | - |
dc.contributor.author | Choi, Kyung Mook | - |
dc.contributor.author | Chin, Juhee | - |
dc.contributor.author | Park, Kun-Woo | - |
dc.contributor.author | Hong, Seung Bong | - |
dc.creator | 정기영 | - |
dc.date.accessioned | 2014-05-19T02:52:00Z | - |
dc.date.available | 2014-05-19T02:52:00Z | - |
dc.date.issued | 2010-09 | - |
dc.identifier.citation | Clinical Neurophysiology, Vol.121 No.9, pp. 1494-1501 | - |
dc.identifier.issn | 1388-2457 | - |
dc.identifier.uri | https://hdl.handle.net/10371/91796 | - |
dc.description.abstract | Objective: To evaluate the effect of topiramate (TPM) on event-related potentials (ERPs) in patients with epilepsy.Methods: Neuropsychological tests and ERP study using auditory oddball paradigm were conducted before and after treatment with TPM in drug-naive epilepsy patients. To detect target brain regions in which ERP changed during the cognitive task, cortical current densities of ERP components were analysed using standardised low-resolution electromagnetic tomography (sLORETA).Results: Neuropsychological tests (n = 18 patients) showed that TPM significantly decreased the score in digit span, Corsi block and Controlled Oral Word Association word fluency. Repeated-measures analysis of variance of ERP data (n = 13 patients) revealed that P2 amplitude was significantly increased at Fz electrode following treatment with TPM. Statistical non-parametric map of sLORETA between pre- and post-TPM ERPs revealed that current density of P200 component was significantly reduced by TPM in bilateral parieto-occipital, temporolimbic and dorsolateral right prefrontal regions.Conclusions: Our findings suggest that TPM affects selective brain regions which may be related to cognitive side effects.Significance: Source localisation of ERPs can be helpful in identifying target brain regions for the cognitive side effects of anti-epileptic drugs. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | 공학 | en |
dc.subject | Topiramate | - |
dc.subject | Cognitive function | - |
dc.subject | Event-related potential (ERP) | - |
dc.subject | Standardised low-resolution | - |
dc.subject | electromagnetic tomography (sLORETA) | - |
dc.subject | Source localisation | - |
dc.title | Cognitive effects of topiramate revealed by standardised low-resolution brain electromagnetic tomography (sLORETA) of event-related potentials | en |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 정기영 | - |
dc.contributor.AlternativeAuthor | 조재욱 | - |
dc.contributor.AlternativeAuthor | 주은연 | - |
dc.contributor.AlternativeAuthor | 김선화 | - |
dc.contributor.AlternativeAuthor | 최경묵 | - |
dc.contributor.AlternativeAuthor | 진주희 | - |
dc.contributor.AlternativeAuthor | 박건우 | - |
dc.contributor.AlternativeAuthor | 홍승봉 | - |
dc.identifier.doi | 10.1016/j.clinph.2010.03.013 | - |
dc.description.srnd | OAIID:oai:osos.snu.ac.kr:snu2010-01/102/2014017262/5 | - |
dc.description.srnd | SEQ:5 | - |
dc.description.srnd | PERF_CD:SNU2010-01 | - |
dc.description.srnd | EVAL_ITEM_CD:102 | - |
dc.description.srnd | USER_ID:2014017262 | - |
dc.description.srnd | ADJUST_YN:Y | - |
dc.description.srnd | EMP_ID:A079623 | - |
dc.description.srnd | DEPT_CD:801 | - |
dc.description.srnd | CITE_RATE:2.786 | - |
dc.description.srnd | DEPT_NM:의학과 | - |
dc.description.srnd | SCOPUS_YN:Y | - |
dc.description.srnd | CONFIRM:Y | - |
dc.identifier.srnd | 2010-01/102/2014017262/5 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.