S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Neurology (신경과학교실) Journal Papers (저널논문_신경과학교실)
Effect of a ketogenic diet on EEG: Analysis of sample entropy
- Yum, Myung-Kul; Jung, Ki-Young; Kang, Hoon-Chul; Kim, Heung Dong; Shon, Young-Min; Kang, Joong-Ku; Lee, Il Keun; Park, Ki-Jong; Kwon, Oh-Young
- Issue Date
- Seizure - European Journal of Epilepsy, Vol.17 No.6, pp. 561-566
- 의약학; Ketogenic diet; EEG; Sample entropy; Anticonvulsive mechanism; Therapeutic responsiveness
- Although ketogenic diet (KD) is an effective alternative therapy for controlling intractable seizures, the anticonvulsant mechanism still remains unclear. Sample entropy (SampEn) provides a generalized measure of regularity in time-series data. To investigate the potential anticonvulsive mechanism of a KD, we analyzed the SampEn of electroencephalography (EEG) data in patients with intractable pediatric epilepsy before and after treatment with a KD. Seventeen pediatric patients with epilepsy who were treated with KD were enrolled in present study. Patients were classified as good responder and poor responder according to therapeutic responsiveness on KD. Thirty segments of 30-s epochs were selected before and after KD from each patient which were subject to SampEn. The KD increased the SampEn in the whole patient population; the SampEn increased significantly in all electrodes in the good responders, but the change in SampEn varied according to the electrode in the poor responders. Before the KD, the good responders had significantly lower SampEn values than the poor responders, but after the KID, SampEn values were higher in the good responders than in the poor responders. KID may have an anticonvulsive effect by decreasing the regularity of the EEG dynamics.
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