신성 고혈압견에 있어서 Renin-Angiotensin-Aldosterone계의 변동에 관한 실험적 연구

Abstract

by partial constriction of their renal artery. After the constriction of renal artery, the changes in blood prossure and body weight were measured every week during the course of experiment for 5 weeks and also simultaneous blood samples were drawn for the analysis of the activities of plasma renin, steroid, aldosterone, and sodium and potassium concentratIOns. The results obtained were as follow; 1. The control mean systolic pressure before operation was 136±22mmHg. After the constriction of renal artery, it was greatly increased within 3 days and rised up to 3weeks continuously, when maximal value of 264±12mmHg. was measured. Thereafter, the pressure was decreased gradually but it remained in highter value than that of control till 5 weeks after operation. 2. control plasma renin activities were averaged 132±57ug%/hr, After operation, the plasma renin activities rised up proportionately with the rise of hlood pressure up to 3 weeks The maximal value at 3 、N e c k s after operation was mean of 317±95μ g/ h r ， which was 2.5 times of the control value. Thereaf• tef, rcain activities were decreased gradually as "the hlood pressure. 3. The control plasma total steroid was means of 6. 25±2. 43/lg% and there were a little variations in that value after the constriction of the renal artery. However, the plasma aldosteron level showed proportional increase. These facts seemed to show that angiotensin stimulates only to secrete aldosterone in adrenal gland. 4 Na levels in plasma after the constriction of the renal artery were proportionately incresed with aldosterone level , while K level vice versa. 5. The changs in body weight after renal hyper tension were from 11.8±0. 8kg in control to 12. 9 ±0.8kg 3 weeks after operation and thereafter it was decreased gradually. The increase in body weight is supposed to mean the degree of edema due to Na retension by aldosterone From the above data, it can be reconfirmed that remarkable disordered function in renin-angiotensinaldosterone system in the renal hypertesion, and that these changes are same with those in the typical secondary aldosteronism.