S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Neurology (신경과학교실) Journal Papers (저널논문_신경과학교실)
심한 폐쇄수면무호흡증후군 환자들의 인지기능장애: 신경심리 검사 및 사건유발전위
Cognitive Dysfunctions in Patients With Severe Obstructive Sleep Apnea Syndrome: Neuropsychological Test and Event-Related Potential Study
- 이동규; 박희정; 김선화; 조재욱; 주은연; 정기영; 홍승봉
- Issue Date
- 대한신경과학회지, Vol.26 No.4, pp. 333-340
- 의약학; Obstructive sleep apnea; Cognition; Attention; Neuropsychological test; Event-related potentials; P300
- Background: Patients with obstructive sleep apnea syndrome (OSAS) show variety of dysfunctions in cognitions including general cognitive function, attention, and frontal lobe and executive function. However, there is no consensus on the main features of the cognitive dysfunction in OSAS patients. So we performed neuropsychological tests and event-related potential (ERP) studies in patients with severe OSAS to evaluate the cognitive dysfunctions and changes of auditory and visual P300.
Methods: Twenty-eight men with severe OSAS (apnea hypopnea index (AHI)=63.1±}17.8/hr) and 16 age, sex, educationmatched normal controls (AHI=2.9±}1.8/hr) underwent neuropsychological tests and ERP studies.
Results: Patients with severe OSAS showed deficits in corsi block forward and backward test during neuropsychological evaluation, and delayed latency and decreased amplitude of auditory P300. There were significant correlations between auditory P300 amplitudes and digit span forward or corsi block forward test scores, and between visual P300 amplitudes and digit symbol test scores.
Conclusions: These findings suggest that severe OSAS patients may have deficits in attention and short-term memory, and abnormal auditory P300.