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신피막제거가 신성고혈압견의 레닌-안지오텐신-알도스테론계에 미치는 영향 : Effects of renal decapsulation on renin-angiotensin-aldosterone system in renal hypertensive dogs
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김명철 | - |
dc.contributor.author | 이상돈 | - |
dc.date.accessioned | 2009-09-14T05:10:50Z | - |
dc.date.available | 2009-09-14T05:10:50Z | - |
dc.date.issued | 1973-12 | - |
dc.identifier.citation | Seoul J Med, Vol.14 No.4, pp. 273-281 | - |
dc.identifier.issn | 0582-6802 | - |
dc.identifier.uri | https://hdl.handle.net/10371/9199 | - |
dc.description.abstract | In 8 mongrel dogs , renal hypertension was produced
by partial constriction of their renal artery and 3 weeks after the constriction of renal artery, reoperation, decapsulation of both kidneys were done in every hypertensive dogs. The changes in blood pressure and body weight were measured every week during the course of experiment for 5 weeks, and also simultaneous blood samples were drawn for analysis of activities of plasma reninl steroid, aldosterone, sodium and potassium concentrations. The results obtained were as follows: 1. The control mean systolic pressure before operation was 136±22 mmHg. After constriction of renal artery, it was greatly increased within 3 days and rised up to 3 weeks continuously when maximum mean value of 264±12 mmHg was measured. However , blood pressure in every hypertensive dogs were gradWllly decreased and return to normal 2 weeks after renal decapsulation. 2. The control plasma renin activities were aver aged 132±57 ng%/hr. After renal constriction, the plasma renin activities rised proportionately with the rise of blood pressure up to 3 weeks. The maximal value at 3 weeks after operation was 2. 5 times of control value. Renin activities were also decreased to almost normal value within 2 weeks by renal decapsulation. . .f 3. There are no signifi따['t , ~ variations in total blood steroid either after renal constriction or renal decapsulation. Aldosterone levels were however proportionately increased or decreased according to the blood renin activities. While , blood Na level was increased and K levels were decreased during renal arterial constriction period but their relations hips were reversed after renal decapsulation. 4. The changes in body weight after constriction of renal artery were increased from 11.8±0. 8kg in control to 12. 9±0. 8 kg. Thereafter these mean values were tend to normal value within 2 weeks after renal decapsulation. The increase in body weight is supposed to mean the degree of edema due to Na retension by aldosterone. From the above data it can be reconfirmed that remarkable disordered function in R-A-A system in the renal hyPertension were same with those in the typical secondary aldosteronism and functions of R-A-A system in the renal hypertensive dogs also tend to return to normal by renal decapsulation. | - |
dc.language.iso | ko | - |
dc.publisher | 서울대학교 의과대학 | - |
dc.title | 신피막제거가 신성고혈압견의 레닌-안지오텐신-알도스테론계에 미치는 영향 | - |
dc.title.alternative | Effects of renal decapsulation on renin-angiotensin-aldosterone system in renal hypertensive dogs | - |
dc.type | SNU Journal | - |
dc.contributor.AlternativeAuthor | Kim, Myeng Cheul | - |
dc.contributor.AlternativeAuthor | Rhee, Sang Don | - |
dc.citation.journaltitle | 서울 의대 잡지 | - |
dc.citation.journaltitle | 서울 의대 학술지 | - |
dc.citation.journaltitle | Seoul Journal of Medicine | - |
dc.citation.endpage | 281 | - |
dc.citation.number | 4 | - |
dc.citation.pages | 273-281 | - |
dc.citation.startpage | 273 | - |
dc.citation.volume | 14 | - |
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