인삼 각 Fraction이 Histamine, Serotonin 유리에 미치는 영향

Abstract

Saponin. non-saponin and oil fractions were separatively extracted from Panax Ginseng C.A. Meyer. and a comparative study was made on their effect to Histamine and Serotonin liberation. and to rabbits blood pressure and respiration. Saponin fraction transitorily decreased rabbits blood pressure slightly and gave no effect to its respiration. Non-saponin fraction also transitorily decreased its blood pressure less than saponin fraction. Oil fraction prolonged its blood pressure falling-down even with small dose. similar to the effect of alcohol extract of panax ginseng. and increased its respiration. Saponin and oil fractions brou앙ht about the phenomenon of tachyphylaxis. Saponin and oil fractions remarkably increased capillarie permeability phenomenon. Only non-saponin fraction made histamine liberation from rats hind-quarter perfusate. which was confirmed by bioassay method. Ginseng saponin had less fish poison action and hemolysis phenomenon than gypsophila saponin. Ginseng fractions liberated Serotonin during rabbits brain perfusion, and incredsed Serotonin content in rats venous blood except oil fraction , and decreased Serotonin content in rat instestine. Ginseng fractions increased the Serotonin content of Iproniazid treated rat blood in vivo , and also increased the 5-Hydroxy Tryptophane Decarboxylase activity of rat kidney in vitro experiment. Ginseng fractions increased the amount of 5-Hydroxy Indol Acetic Acid urinaly excretion except oil fraction. Ginseng fractions decreased the numbers of Entero Chromaffin cells in proportion to the decrease of the Serotonin content in rats intestine.