Glycyrrhizine이 부신피질 Hormone분비에 미치는 영향에 관한 실험적 연구

Abstract

After reviewing studies of many workers concerning the pharmacological similarity of Glycyrrhizine. an active principle of Licor ice. to adrenal corticoids. the author has conducted a series of experimental studies to explore the complex mechanism of the said substance in presence and absence of adrenal glands , arriving at the following l;onclusions: 1. Seven day administration of Glycyrrhizine resu! ted in a blood picture with experimental mice tending to erythrocytosis, leucopenia. lymphopenia. and neutrophillia. 2. Single or prolonged administration of Glycyrrhizine proved a tendency of per cent decrease of circulating eosinophils with intact rats, in contrast with adrenalectomized rats lacking such tendency. while cortisone showed a reverse effect with the latter group. 3. Seven day administration of Glycyrrhizine caused a decrease in the sodium content of urinary excretion with rats and increase in the potassium content. 4. Seven day administration of Glycyrrhizine increased adrenal ascorbic acid content of hitaminestressed rats. 5. Seven day administration of Glycyrrhizine increased adrenal cholesterol contents with both histamine-stressed and non-stress group of rats. The degree of adrenal cholesterol depletion in response to stress was the same in treated and control animals. 6. The blood sugar level with the group of rabbits which fasted 48 hours following one week of Glycyrrhizine administration turned out to be markedly higher than the control group. 7. Seven day administration of cortisone and DCA appeared to prevent hypotention usually caused by adrenalectomy and alleviated drop in blood pressure by histamine stress. but Glycyrrhizine showed none of these effects. 8. Prolonged administration of Glycyrrhizine appeared to bring about glycogen deposition with liver of rats. cortex atrophy and decrease of Sudanophilic substance in adrenal glands. and tubular dilatation accompanied by atrophy of tubular cells and degenerative vascular changes in kidneys.