창출정유의 Serotonin 유리에 미치는 영향에 관한 실험적 연구

Abstract

The effects of Atractylol oil on the blood pressure, 5-hydroxytryptamine (Serotonin, 5 HT) liberation, monoamine oxidase-, decarboxylase activity and urinary excretion of 5-hydroxyindole acetic acid (5 HIA A) were studied and compared with those of reserpine. 1. A small dose of Atractylol oil caused transitory, while a larger dose sustaining fall of blood pressure. 2. 5 HT liberation of rabbit brain perfusate reached its peak at 10.to 20 minutes after the administration of Atractylol oil, which was followed by a gradual decrease. This similar effects were observed with reserpme. 3. Intestinal 5 HT content of rat appeared to decrease by both of Atractylol oil and reserpine, in which the effect of Atractylol oil was more marked than reserpine. 4. Venous blood 5 HT content of rat tended to increase by both of Atractylol oil and reserpine, in which the effect of Atractylol oil was also more marked than reserpine. The similar effect were observed in the l-isopropyl-2-isonicotinylhydrazine (iproniazid) (IIH)treated animals , however , there existed no differences between Atractylol oil and reserpine. 5. Atractylol oil and reserpine tended to increase the decarboxylse activity of the rat kidney. The ratios of increase were 1.08 with Atractylol oil and 1. 21 with reserpine, provided for the mean value in control animals was 1. O. 6. 5 HIAA urinary excretion in rats tended to increase in Atractylol oil and reserpine administrated animal groups. The effect of Atractylol oil was more prominent than that of reserpine.