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RimabotulinumtoxinB versus OnabotulinumtoxinA in the Treatment of Masseter Hypertrophy: A 24-Week Double-Blind Randomized Split-Face Study

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Authors
Lee, Dong Hun; Jin, Seon-Pil; Cho, Soyun; Feneran, Ashley; Youn, Choon Shik; Won, Chong Hyun; Park, Gyeong-Hun; Kim, Byung Wook; An, Jeesoo; Chang, Sung Eun; Lee, Mi Woo
Issue Date
2013-06
Publisher
Karger
Citation
Dermatology, Vol.226 No.3, pp. 227-232
Keywords
복합학Botulinum toxinMasseter hypertrophyOnabotulinumtoxinARimabotulinumtoxinB
Abstract
Background: Masseter hypertrophy can be ameliorated by botulinum toxin. Objective: To compare the efficacy and safety of RimabotulinumtoxinB (BTX-B) and OnabotulinumtoxinA (BTX-A) in the treatment of masseter hypertrophy. Methods: Sixteen women with bilateral masseter hypertrophy received single injections of BTX-A or BTX-B at a dose ratio of 1:50 or 1:70 in a 24-week double-blind randomized split-face study. Results: Both BTX-A and BTX-B produced significant improvements in masseter hypertrophy. The maximum volume reduction, as determined by computed tomography scanning, at week 12 was comparable between BTX-A and BTX-B at a dose ratio of 1:70 (15.6 and 14.2%, respectively). At week 24, only masseters treated with BTX-A maintained a significant volume reduction. Investigator ratings and patient satisfaction scores paralleled objective computed tomography measurements. Conclusion: Both BTX-A and BTX-B are effective in the treatment of masseter hypertrophy. BTX-B, at a dose ratio of 1:70, has a comparable efficacy but a shorter duration of action than BTX-A. Copyright (C) 2013 S. Karger AG, Basel
ISSN
1018-8665
Language
English
URI
https://hdl.handle.net/10371/92478
DOI
https://doi.org/10.1159/000349984
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College of Medicine/School of Medicine (의과대학/대학원)Dermatology (피부과학전공)Journal Papers (저널논문_피부과학전공)
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