일산화탄소중독에 대한 실험적 연구

Abstract

In view of the frequent incident of acute CO poisoning among Korean residents, who are daily using briquette, the establishment of the effective measures to the poisoned as well as the preventive measures is urgent problems in the field of the public health. Author undertook a series of studies concerning 1) the tolerance of Albino rat to 1% CO, changes in the respiration rate during the exposure, the time of immobilization of rat, and the post-mortem HbCO concentration and the amount of Hb in the blood. 2) The comparison of the different recovery measures, such as, vitamin C injection (lOmg/ l00g B.W. intra-peritoneal), Adrenalin injection(O:·Olmg/l00g B.W. intra-perit-oneaI,).100 % 02 inhalation, 95% 02 1l!us-5% CO2 inhalatioll at 1 Atmos. & r.5 Atmos. , in relation to the recovery time , HbCO concentration when recovered, and the changes in the respiration rate during the recovery, The results might be summarized as follows. 1) Average tolerance time of the Albino rat to 1% CO was 162.4 minutes and the minimal and maximal tolerance time was extended from 30 minutes to 345 minutes. 1) Much of the variarions in the individual tolerance could be observed. 3) The time of the immobilization of rat was directly proportional to the tolerance time. 4) Changes in the respiration rate during the exposure to 1% CO showed a different patterns in the different tolerance group. 5) The saturation of the HbCO and the amount of Hb in the post-mortem blood in each tolerance group showed following results.