인삼이 CCl4에 의한 백서간손상 및 방사선 장해에 미치는 영향에 대하여 : Effect of Panax Ginseng on CCl4 Induced Liver Injury and X-Irradiation Damage in Rats

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서울대학교 의과대학
Seoul J Med, Vol.13 No.1, pp. 1-14
Following experiments were conducted for the
study of Panax Ginseng effect on Cel induced liver
injury and on X•irradiated damage of albino rats.
Male rats of Wistar hybrid, weighing 150±10g,
were divided into 6 groups and first 3 groups were
control, CCI. gh'en, :md the previous Ginseng
decoction given and CCl. administered animals, and
another 3 groups were control, X-irradiated, and
the previous Ginseng decoction administered and
X-irradiated ones. Animals were sacrificed 18 hours
after CCl. administration or 24 hours after X-irradiation
with the dose of 800R. Liver s were removed
immediately for the determination of contents of
ATP, nucleic acids and lipids as well as for the
incorporation of acetate-1-HC into fatty acids in
liver slices. Following results were obtained.
1) The ATP content of CCl. poisoned liver was
12.4±1.4r/ g, show ing much less than 32. I±3. 5r/ g
of control value, and that of Ginseng and CCl. administered
group was 20.6±8r/g, it was thus shown
that the previous administration of Ginseng lessened
the decrease in hepatic ATP content of CCI, given
2) No appreciable alteration was observed in the
hepatic nucleic acid content by the CCI, treatment
with the consequence of no Ginseng effect.
3) The mitochondrial RNA content of CCμ poisoned
liver was not altered 18 hours after CCI. administration.
4) The triglyceride content of CCl. poisoned rats
was 15. 2±4. 2mg/g which was lowered to 9. 8±2. 9
mg/g by the previous Ginseng administration. The
hepatic cholesterol content of CCI. given rats was
10.3±4. Omg/g, comparing with 6. 4±1. Omg/g of
normal value, and the phospholipid content (32.3±
6.1mg/g) of CCI. poisoned liver was decreased as
compared to 38. 9±4. 8mg/g of control value. The
previous administration of Ginseng caused to normalize
significantly such a change of cholesterol and
phospholipid content.
5) The incorporation of acetate-I-HC into the triglyceride
was much increased with cpm of 1.821
±325 in liver slices of CCI, poisoned rats, as compared
to the control value of 1.072±247. The synthesis
of fatty acids was thus shown to be increased ,
reflecting the marked increase in hepatic triglyceride
in CCl. administered rats. This isotopic incorporation
rate in liver slices of Ginseng administered group
was shown to be intermediate between the value인 of
normal and Cel, treated animals.
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 13 No.1 (1972)
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