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Genetic Influences on Hallux Valgus in Koreans: The Healthy Twin Study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Chang-Hyung | - |
dc.contributor.author | Lee, Sooji | - |
dc.contributor.author | Kang, HyoJeong | - |
dc.contributor.author | Jung, Da-Eun | - |
dc.contributor.author | Song, Yun-Mi | - |
dc.contributor.author | Lee, Kayoung | - |
dc.contributor.author | Lee, Kyungtai | - |
dc.contributor.author | Hwang, JiHye | - |
dc.contributor.author | Sung, Joohon | - |
dc.creator | 성주헌 | - |
dc.date.accessioned | 2014-07-22T02:25:04Z | - |
dc.date.available | 2014-07-22T02:25:04Z | - |
dc.date.issued | 2014-03 | - |
dc.identifier.citation | Twin Research and Human Genetics, Vol.17 No.2, pp. 121-126 | - |
dc.identifier.issn | 1832-4274 | - |
dc.identifier.uri | https://hdl.handle.net/10371/92537 | - |
dc.description.abstract | Hallux valgus (HV) is a common foot deformity of multifactorial etiology, but knowledge about the relative importance of genetics and environments on HV has been limited. In order to estimate genetic influences on HV, 1,265 adults, including 175 monozygotic twin (MZ) pairs, 31 dizygotic twin (DZ) pairs, and 853 first-degree singleton family members of the twins were included from the Healthy Twin study, a population-based twin-family cohort in Korea. All participants underwent foot examination and weight-bearing radiographic assessment (anterior-posterior and lateral) in addition to a general health survey. Of the subjects, 208 (16.4%) were classified as HV (as HV angle >20 degrees). The genetic influence on HV was estimated to be substantial; the heritability of HV was 0.51 (95% CI 0.42-0.59) and the heritability of HV angle was 0.47 (0.38-0.56), while contributions from shared environmental effects were negligible. These findings suggest that genetic factors play an important role in determining HV deformity. | en |
dc.language.iso | en | en |
dc.publisher | Cambridge University Press | en |
dc.subject | 복합학 | en |
dc.subject | foot disease | - |
dc.subject | hallux valgus | - |
dc.subject | deformity of foot | - |
dc.subject | genetic epidemiology | - |
dc.subject | twin research | - |
dc.subject | Koreans | - |
dc.subject | Asiatic races | - |
dc.title | Genetic Influences on Hallux Valgus in Koreans: The Healthy Twin Study | en |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 이창형 | - |
dc.contributor.AlternativeAuthor | 이수지 | - |
dc.contributor.AlternativeAuthor | 강효정 | - |
dc.contributor.AlternativeAuthor | 정다은 | - |
dc.contributor.AlternativeAuthor | 송윤미 | - |
dc.contributor.AlternativeAuthor | 이가영 | - |
dc.contributor.AlternativeAuthor | 이경태 | - |
dc.contributor.AlternativeAuthor | 황지혜 | - |
dc.contributor.AlternativeAuthor | 성주헌 | - |
dc.identifier.doi | 10.1017/thg.2014.10 | - |
dc.description.srnd | OAIID:oai:osos.snu.ac.kr:snu2014-01/102/0000040632/3 | - |
dc.description.srnd | SEQ:3 | - |
dc.description.srnd | PERF_CD:SNU2014-01 | - |
dc.description.srnd | EVAL_ITEM_CD:102 | - |
dc.description.srnd | USER_ID:0000040632 | - |
dc.description.srnd | ADJUST_YN:Y | - |
dc.description.srnd | EMP_ID:A077602 | - |
dc.description.srnd | DEPT_CD:902 | - |
dc.description.srnd | CITE_RATE:1.635 | - |
dc.description.srnd | FILENAME:3.genetic influences on hallux valgus in koreans_pgm_grn_nrf_bk21.pdf | - |
dc.description.srnd | DEPT_NM:보건학과 | - |
dc.description.srnd | SCOPUS_YN:Y | - |
dc.description.srnd | CONFIRM:Y | - |
dc.identifier.srnd | 2014-01/102/0000040632/3 | - |
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