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Bacteriophage Therapy of a Vibrio parahaemolyticus Infection Caused by a Multiple-Antibiotic?Resistant O3:K6 Pandemic Clinical Strain

Cited 52 time in Web of Science Cited 56 time in Scopus
Authors
Jun, Jin Woo; Shin, Tae Hoon; Kim, Ji Hyung; Shin, Sang Phil; Han, Jee Eun; Heo, Gang Joon; Zoysa, Mahanama De; Shin, Gee Wook; Chai, Ji Young; Park, Se Chang
Issue Date
2014-07
Publisher
Oxford University Press
Citation
Journal of Infectious Diseases, Vol.210 No.1, pp. 72-78
Keywords
의약학Vibrio parahaemolyticusbacteriophagepVp-1pandemic strains
Abstract
Background. Recently isolated Vibrio parahaemolyticus strains have displayed multiple antibiotic resistance. Alternatives to conventional antibiotics are needed, especially for the multiple-antibiotic–resistant V. parahaemolyticus pandemic strain.

Methods. A bacteriophage, designated pVp-1, showed effective infectivity for multiple-antibiotic–resistant V. parahaemolyticus and V. vulnificus, including V. parahaemolyticus pandemic strains. The therapeutic potential of the phage was studied in a mouse model of experimental infection using a multiple-antibiotic–resistant V. parahaemolyticus pandemic strain. We monitored the survivability and histopathological changes, quantified the bacterial and phage titers during phage therapy, and observed the immune response induced by phage induction.

Results. Phage-treated mice displayed protection from a V. parahaemolyticus infection and survived lethal oral and intraperitoneal bacterial challenges.

Conclusions. To the best of our knowledge, this is the first report of phage therapy in a mouse model against a multiple-antibiotic–resistant V. parahaemolyticus pandemic strain infection.
ISSN
0022-1899
Language
English
URI
https://hdl.handle.net/10371/92538
DOI
https://doi.org/10.1093/infdis/jiu059
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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