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토끼 LDH isoenzyme의 특성과 인삼분획이 미치는 영향에 관한 연구
A STUDY ON THE PROPERTIES OF RABBIT LDH ISOENZYMES AND ON THE EFFECT OF GINSENG FRACTIONS ON THEM

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Authors
신용찬; 김승원
Issue Date
1972-06
Publisher
서울대학교 의과대학
Citation
Seoul J Med, Vol.13 No.2, pp. 71-82
Abstract
Five types of l.1ctate dehydrogenase (LDH)
have been identified in mammalian tissues by
starch-gel electrophoresis (Markert and M¢ller,
1959), LDH-1 being nearest the anode , and
LDH-5 nearest the cathode. It is now well
established (Cahn et al. , 1962) that each
isoenzyme is composed of four polypeptide
chains which are assembled from two different
polypeptide units, A and B, as designa•
ted by Markert (1961) (M and H by Cahn et
al. , 1962).
LDH isoenzyme 1 through 5, therefore,
have the following polypeptide compositions:
AoB4, AjB3, AzBz, A3Bj and A4Bo. Since the
synthesis of the A and B polypeptides is
controlled by two different genes (Markert,
1963), the phenotypic expression of the LDH
isoenzyme pattern of any tissue or cell is
known to be dependent on the relative activity
of these two genes.
The proportions of the LDH isoenzymes
have been observed to change during the
development of various tissues from rat (Fine,
Kaplan and Kuftireclι 1963), chick (Chan et
al. , 1962: Nebel and Coklin , 1965). rabbit
(Vessell, Philip and Beam, 1962) and human
(Fine, Kaplan and Kuftireclι 1963: Latner
and Skiller, 1964), which suggests that the
two structural genes are under independent
but possibly linked control.
Attention has been directed chiefly towards
liver and skeletal muscle in which the proportions
of the more slowly migrating M-containing
isoenzymes increase during development,
and towards heart where the proportions of
H-containing isoenzymes increase during development.
ISSN
0582-6802
Language
English
URI
http://hdl.handle.net/10371/9261
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 13 No.2 (1972)
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