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하지불안증후군이 중추신경계 질환임을 시사하는 임상적, 신경영상학적, 신경생리학적 증거들에 관하여 : Clinical, Neuroimaging and Neurophysiologic Evidences of Restless Legs Syndrome as a Disorder of Central Nervous System
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- Authors
- Issue Date
- 2008
- Publisher
- 대한임상신경생리학회
- Citation
- 대한임상신경생리학회지, Vol.10, No.2, pp. 98-100
- Keywords
- 의약학 ; Restless legs syndrome ; dopamine ; iron ; A11 neuron
- Abstract
- Restless legs syndrome (RLS) is a sensorimotor neurological disorder in which the primary symptom is a compelling
urge to move the legs, accompanied by unpleasant and disturbing sensations in the legs. Although pathophysiologic
mechanism of RLS is still unclear, several evidences suggest that RLS is related to dysfunction in central nervous system
involving brain and spinal cord. L-DOPA, as the precursor of dopamine, as well as dopamine agonists, plays an essential
role in the treatment of RLS leading to the assumption of a key role of dopamine function in the pathophysiology of
RLS. Patients with RLS have lower levels of dopamine in the substantia nigra and respond to iron administration. Iron,
as a cofactor in dopamine production, plays a central role in the etiology of RLS. Functional neuroimaging studies using
PET and SPECT support a central striatal D2 receptor abnormality in the pathophysiology of RLS. Functional MRI
suggested a central generator of periodic limb movements during sleep (PLMs) in RLS. However, to date, we have no
direct evidence of pathogenic mechanisms of RLS.
- ISSN
- 1229-6414
- Language
- Korean
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