S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Medicine (의학과) The Seoul Journal of Medicine The Seoul Journal of Medicine Vol. 13 No.2 (1972)
한국인뇨의 베타-aminoisobutyric acid 배설에 관한 연구
Studies on Urine BAIB Excretion of Normal Koreans
- Issue Date
- 서울대학교 의과대학
- Seoul J Med, Vol.13 No.2, pp. 109-119
- The urinary excretion of fi-aminoisobutyric acid
(BlAB) was surveyed on the Korean population
including 173 males and 169 females.
The urine BAlE content was determined employing
paper electrophoresis at the high voltage gradient. The concentration of BAIB was expressed on the
basis of creatinine amount. Following results were
(1) No appreciable daily fluctuation of BAlE
excretion was observed for 3 normal individuals by
the consecutive determination for 7 days.
(2) The urine BAlE amount of normal 342 Kereans
varied widely ranging from 1 to 187pg/mg creatinine.
On the assumption of BAlE excretor for the con •
~ 'centration above 30mg/g creatinine, BAlE excretors
were shown to be 34.2% among the subjects
examined. 36.4% for males and 32.0% for females.
Assuming high BAlE excretor for Individuals above
50pg excretion, high excretors among Korean
peoples were 21. 5%, including 21.4% for males and
20.7% for females.
(3) The results provided strong evidence for the
bimodal distribution rather than normal one of BAlE
concentration in urine among Korean population and
this was the cases for both sexes in our investiga•
tion. Thus, this suggested that the BAlE excretion
might be controlled by one pair of alleles. Although
bimodality of the distribution of urine BAIB concentration
was overlapped. the antimode of distribution
is apparently 1. 5(=log 31. 6) in our investigation.
(4) The average content of urine BAlE was much
higher in the subjects under 10 years of age. comparing
with that of other age groups. Thus, the
elimination of subjects under 10 years should be
recommended in such an anthropological study.
(5) The frequency of 13AIB excretors in Korean
people was proved to be much higher than that of
Caucasians as other Orientals, but slightly less than
that of other Oriental Peoples.