한국인뇨의 베타-aminoisobutyric acid 배설에 관한 연구

Abstract

The urinary excretion of fi-aminoisobutyric acid (BlAB) was surveyed on the Korean population including 173 males and 169 females. The urine BAlE content was determined employing paper electrophoresis at the high voltage gradient. The concentration of BAIB was expressed on the basis of creatinine amount. Following results were obtained. (1) No appreciable daily fluctuation of BAlE excretion was observed for 3 normal individuals by the consecutive determination for 7 days. (2) The urine BAlE amount of normal 342 Kereans varied widely ranging from 1 to 187pg/mg creatinine. On the assumption of BAlE excretor for the con • ~ 'centration above 30mg/g creatinine, BAlE excretors were shown to be 34.2% among the subjects examined. 36.4% for males and 32.0% for females. Assuming high BAlE excretor for Individuals above 50pg excretion, high excretors among Korean peoples were 21. 5%, including 21.4% for males and 20.7% for females. (3) The results provided strong evidence for the bimodal distribution rather than normal one of BAlE concentration in urine among Korean population and this was the cases for both sexes in our investiga• tion. Thus, this suggested that the BAlE excretion might be controlled by one pair of alleles. Although bimodality of the distribution of urine BAIB concentration was overlapped. the antimode of distribution is apparently 1. 5(=log 31. 6) in our investigation. (4) The average content of urine BAlE was much higher in the subjects under 10 years of age. comparing with that of other age groups. Thus, the elimination of subjects under 10 years should be recommended in such an anthropological study. (5) The frequency of 13AIB excretors in Korean people was proved to be much higher than that of Caucasians as other Orientals, but slightly less than that of other Oriental Peoples.