알카로이드계열 한약제의 간독성에 관한 실험적 연구 제1편 간거대세포현상

Abstract

A histopathologic reappraisal of lasiocarpine(pyrrolizidine alkaloid)-induced megalocytosis of the liver on rats was carried out. as an attempt to compare with similar hepatic cell alterations encountered frequently among Koreans and to clarify its biological significance on those phenomena. Megalocytosis. a characteristic hepatic cell unrest, was found in groups of lasiocarpine and p-dimethylaminoazobenzene administration. but much advanced in animals treated with lasiocarpine and p-dimethylaminoazobenzene together, being progressive and constant with prolongation of experimental duration and regenerative activity of underlying hepatic tissue. Megalocytosis produced in rats was cytologically and histoioglcally quite similar or nearly identical to those seen in 27 cases of liver biopsy materials with history of taking herb-medicine in 23 Koreans. It 섭i s 이0 f a따ulth야oIr냥 0때p미i띠nl너i o n that demonstration 이0f hepatic mega띠loc야ytosis is one of important histologic criteria to screen hepatotoxicity of herb medicine in Korea.