미만성 혈관내 응고항진에 관한 연구

Abstract

Infusing 150 units of thrombin per animal into the ear vein of rabbits for one hour, coagulatiort studies-platelet counts, fibrinogen concentration, prothrombin time and partial thromboplastin time were performed on the arterial blood from aorta and the venous blood from inferior vena cava, renal vein and portal vein at one hour and two hours respecti vely following infusion. The same observation was also performed on the rabbits injected prior to thrombin infusion with a controlled doses of heparin, persantin, epsilon aminocaproic acid (EACA), histamine and norepinephrine respectively. The results are summerized as follows: 1. Thrombin infused rabbits exhibited not only prolongation of prothrom1:Jin time and partial thromboplastin time, but marked decrease in fibrinogen concentration and platelets counts particulary in the venous blood from renal vein and the arterial blood from aorta. 2. Injection of heprain, EACA and persantin prior to thrombin infusion inhibited the above effects of thrombin on coagulation factors. 3. Injection of histamine and norepinephrine inje ction prior to thrombin infusion aggravated the effect of thrombin on platelet counts in the thrombin infused rabbits. 4. Heparin exerted marked influence on the venous blood from renal vein, persantin on the venous blood from portal vein and histamine on the venous blood from inferior vena cava.