폐흡충(Paragonimus Wesermani) 및 췌질(Eurytrema Pancreaticum)의 포도당대사에 관한 연구

Abstract

Metabolic studies on the parasites are of great interest in comparative physiology, and important for the understanding of hostparasite relationship, rational diagnosis and treatment of the parasites. There have been many contributions in the studies of carbohydrate metabolism in parasitic helminthes, but only a little informations are available concerning the intermediary metabolism of carbohydrate in trematodes. Recently, radioactive isotope labeled carbohydrate has served to elucidate the various metabolic schemes of a certain trematodes. In the chinese liver fluke, Cloηorchis sinensis , considerable amount of exogenous HCglucose was absorbed (Hahn et aI. , 1961), and the distributio '1 of this labeled substance was demonstrated by autoradiography (Hahn et aI. , 1962: Seo & Lee, 1971). Kang et al. (1969) showed the evidences of anaerobic glycolysis and Krebs cycle activity in this fluke by me3ns of chrvmatography combined with au toradiography. Bryant & \Villiams (1962) found relatively high percentage of the labeled carbon in glycolytic intermediates and end products in Fasciola hepa tt'ca. Seo et al. (1964a) studied on the quantitative analysis of the metabolic process of exogenous HC-glucose by F. hepatica, and similar experiments were carried out by Eμrytrema paηcreaticμm (Seo et aI. , 1964b), and Paramphz'stomum cervi (Seo et aI. , 1965a). Park et al. (1967) clarified the uptake and distribution of HC-succinate in E. pancreaticum and it was also studied by C. siηeηsis (Hahn 1971) by means of macroand microautoradiography. Thersell et al. (1968) observed the fate and distribution of HC-glucose by using autoradiography, paper electrophoresis and paper chromatograph} by F. hepatica. By the lung fluke, Paragonimus westermaηi， Hamajima (1966a, b & 1967) had proved the intermediary metabolites of carbohydrate and protein by means of chromatography.