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Ouabain이 Ca++-Troponin 상호작용에 미치는 영향 : The effect of ouabain on Ca++-troponin interaction
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정명희 | - |
dc.contributor.author | 홍사악 | - |
dc.contributor.author | 박찬웅 | - |
dc.date.accessioned | 2009-09-14T15:21:32Z | - |
dc.date.available | 2009-09-14T15:21:32Z | - |
dc.date.issued | 1972-12 | - |
dc.identifier.citation | Seoul J Med, Vol.13 No.4, pp. 261-267 | - |
dc.identifier.issn | 0582-6802 | - |
dc.identifier.uri | https://hdl.handle.net/10371/9278 | - |
dc.description.abstract | The possible mechanism of inotropic action of
cardiac glycosides(CG) have been sought with respects to the cellular and intracellular mobi1izatiop of calcium. But calcium, which plays a triggering role in excitation-contraction coupling, acts upon the contractile protein, esp. troponin. eventually stimulates ATPase activity of actomyosin and induces the muscular contraction. Although many investigations were devoted to search for the possible effects of CG on the contractile protein, no conclusive evidence for a direct interference of CG with the physicochemical or enzymatic properties of the actomyosin is available. Present study was made to observe the effect of ouabain on the Catt-troponin interaction in the superprecipitation of actomyosion. The results are summarized as follows. 1. The initiation of the superprecipitation of natural actomyosin was delayed by adding EGTA before the superprecipitation reaction. This delayed initiation by EGT A was not affected by ouabain. 2. The addition of EGT A during the superprecipitation caused the superprecipitation curve to be declined nearly to the level before the reaction. This clearing effect of EGT A on superprecipitation was reversed by ouabain. which also accelerated curve to reach the maximum more rapidly. 3. Above effect of ouabain showed the doseresponse manner. 4. Di git onin did not show such effect as ouabain did. 5. Above effect of ouabain on the action of EGT A during the reaction also obtained from the Perry myosin B superprecipitation in the presence of troponin and tropomyosin. 6. It is suggested that ouabain affects the troponincalcium interaction and alters the binding property of calcium to the troponin. | - |
dc.language.iso | en | - |
dc.publisher | 서울대학교 의과대학 | - |
dc.title | Ouabain이 Ca++-Troponin 상호작용에 미치는 영향 | - |
dc.title.alternative | The effect of ouabain on Ca++-troponin interaction | - |
dc.type | SNU Journal | - |
dc.contributor.AlternativeAuthor | Hong, S. A. | - |
dc.contributor.AlternativeAuthor | Chung, M. H. | - |
dc.contributor.AlternativeAuthor | Park, C. W. | - |
dc.citation.journaltitle | 서울 의대 잡지 | - |
dc.citation.journaltitle | 서울 의대 학술지 | - |
dc.citation.journaltitle | Seoul Journal of Medicine | - |
dc.citation.endpage | 267 | - |
dc.citation.number | 4 | - |
dc.citation.pages | 261-267 | - |
dc.citation.startpage | 261 | - |
dc.citation.volume | 13 | - |
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