Effects of Clofibrats on Carbon Tetrachloride Induced Fatty Liver in Rats-With Special Reference to liver Triglycerides- : Clofibrate가 사염화탄소(CCl4)유발백서 지방간의 지질량에 미치는 영향

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서울대학교 의과대학
Seoul J Med, Vol.10 No.4, pp. 49-63
In 1962, Thorp and Waring!) reported that
administration in rats of clofibrate (ethyl 2(
p - chlorophenoxy)-2-methylpropionate= ethyl
p-chlorphenoxyisobutyrate, Atromid-S, see
Fig. 1) and the combination of clofibrate
with androsterone (Atromid)reduced the plasma cholesterol level. Later in
the same year OIiver2) showed that Atromid
lowered elevated serum cholesterol and triglycerides
(TG) levels in man. Subsequently,
however3) , Oliver himself demonstrated that
the administration of clofibrate alone was as
effective as Atromid. Since these earlier papers ,
considerably more experience has been gained
concerning the effect of clofibrate, and now it
seems well established that clofibrate decrease
plasma levels both of TG and cholesterol in
humans and rats although the mechanism of
this effect has not been fully defined. The
active form of clofibrate in vivo seems to be
the free chlorophenoxyisobutyric am] (C. P.
I. E ) bound to albumin 4)
On the other hand, the induction of a fatty
liver in experimental animals following the
administration of carbon itetrachloride (CCI4)
has been amply documented5- 7) . The etiology
for the accumulation of hepatic fats by CC14
has not been settled5) , but chemical investigation
revealed that the rise in liver lipids
following CCI4 was primarily due to increased
hepatic TG6). Most studies field in the past aimed
at obtaining the greater knowledge regarding
mechanism by which human liver damage is
produced, but in recent years this model has
been used in study of lipid, especially TG,
metabolism8 9) At the present time available
evidences support the hypothesis that such an
accumulation of lipids in liver tissue by CC14
is due to a block in the transfer of TG from
the liver to the plasma!O, 14) •
Thus clofibrate and carbon tetrachloride both
undoubtedly produce wide spread effect on
lipid metabolism in living organism. It would
be most interesting at this stage to see the
effects of clofibrate on liver lipids, especially
TG, of CCI4 intoxicated rats, which may help
for the elucidation of mechanisms involved in
the action of clofibrate as well as that of
CC1 4•
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 07 No.4 (1966)
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