실험적 일산화탄소(CO) 중독과 대뇌 GABA 및 Glutamic Acid

Abstract

One of the everyday risks, especially in winter season, to which we Koreans are exposed nowadays has become the poisoning with crbon monoxide (CO) which, together with other noxious substances such as S02,NO, H2S, N02, formaldehde, etc. , '~manates from most Korean household heating fuel anthracite CO poisoning is now threatening hundreds, or more lives across the country every year(l) in Korea. CO poisoning has not only to do with the system of home heating and cooking devices in Korea but also to do with industry, occupational sources, motor vrnicle exhaust, tobacco smoking, etc , all over the world. It must be necessary to deVf~lop adquate socio-economic pregramming and policies to prevent the adverse effects of CO poisoning on our health. of course. Of more urgent in our opinion is to understand one very nature of CO poisoning in its basis by way of long-range scientific research, rather than impatient search for practical or immediately applicalble measures against CO poisoning most policy-makers seek. The problem of whether or not the CO poisoning result solely from anoxia , for example, has not been solved. While biochemical studies associated with CO poisoning are needed in this regard, experimental studies so far has been mostly purely biological, such as those dealing with morbidity and/or mortality as related to co concentration(2,3), etc. Since many of the symptoms of CO poisoning are more or less of central nervous system, and gammaaminobutyric acid(GABA) appears to be an inhibitory factor in the brain while the glutamic acid excitatory, attempts were made to demonstrate relationship, if any, between the brain content of these amino acids and experimentally produced CO poisoning primarilly. Experimental set-ups were further extended to what have in some aspects to do with CO poisoning, i e hyperbaric oxygenation , with and without pre ceeding CO poisoning, hypoxic state and state of drug-induced anesthesia.