Browse

히스타민이 저분극된 토끼 유두근의 전기적 및 기계적 성질에 미치는 영향
Effect of histamine on the electrical and mechanical properties of potassium depolarized rabbit papillary muscle

Cited 0 time in Web of Science Cited 0 time in Scopus
Authors
엄융의; 김중수
Issue Date
1978-03
Publisher
서울대학교 의과대학
Citation
Seoul J Med, Vol.19 No.1, pp. 10-14
Abstract
Electrophysiological and mechanical effects of histamine
were investigated in rabbit papillary muscle
partially depolarized by elevation of potassium concentration
to 27mM.
1. Histamine increased peak tension from 112±
5.2% in O. 1pM to 180±3.796 in 30μM of control
value in normal Tyrode solution
2. In 27mM K+ Tyrode solution. papillary muscle
was depolarized from -80±2.2mV of normal resting
potential to-41±1. 7mV and there were no pro
pagated action potential and contraction by ordinary
stimulation.
3. Action potential and contraction were restored
in the concentration of O. 1~30μM histamine in 27mM
K+ Tyrode solution.
4. Mechanical tension changed with the concentration
of histamine, from 41±4.5% in O.lpM to 96±
3.7% in 10pM of the value of 30μM histamine
5. Maximum rate of depolarization (Vmax) and
overshoot voltage of action potential in depolarized
papillary muscle increased with the concentration of
histamine in the range of O. 1~30μM from 6±0.8
VIsec and 28±0.8mV in 0.1μM to 16. 7±0. 3 VIsec
and 35±0. 2mV in 30μM
6. Duration of action potential restored by histamine
was not changed significantly with its concentration
ISSN
0582-6802
Language
Korean
URI
http://hdl.handle.net/10371/9344
Files in This Item:
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 19 No.1 (1978)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse