한국인 혈청 Cholinesterase에 관한 연구

Abstract

Serum cholinesterase activities using benzoylcholine as substrate have been measured in 1,284 patients admitted at Seoul National University Hospital during May, 1977 to March , 1978. Dibucaine numbers and fluoride numbers have been determined in all cases Total serum cholinesterase activities in 1.216 patil'llts who have HonnaI DN and FN si lO 、"cd 128.96+ ~~. IS pmolc/ml ~crum/hr. Phenotypic distribution of DNs was found to be normal=95.64% , intermediate =3.5%, atypical=0.78% and FNs was found to be normal 97.20%, intermediate=2.18%, atypical=O. 62%. The frequency of the atypical gene of DN as calculated from these data by applying Hardy-Weinberg Law was 0.0257